Tracheal gas insufflation reduces requirements for mechanical ventilation in a rabbit model of respiratory distress syndrome

Details

Serval ID
serval:BIB_6E44428209AF
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Tracheal gas insufflation reduces requirements for mechanical ventilation in a rabbit model of respiratory distress syndrome
Journal
Anaesthesia and Intensive Care
Author(s)
Bernath  M. A., Henning  R.
ISSN
0310-057X
Publication state
Published
Issued date
02/1997
Peer-reviewed
Oui
Volume
25
Number
1
Pages
15-22
Notes
Journal Article --- Old month value: Feb
Abstract
Tracheal gas insufflation is known to lower PaCO2 in larger animal models of respiratory distress syndrome, but its ability to reduce the ventilator pressures and tidal volume needed to achieve an acceptable PaCO2 has not been examined in small animals using modes of ventilation employed in neonatal intensive care. In this study, the effect of insufflating humidified gas into the lower trachea was examined in a saline lung lavage model of respiratory distress syndrome in rabbits, while the peak airway pressure during conventional pressure-limited ventilation was adjusted to keep the PaCO2 approximately constant. Tracheal gas insufflation significantly reduced the peak airway pressure required and reduced the delivered tidal volume but did not affect the AaDO2. The effects were more marked at a ventilator rate of 30 breaths per minute than at 60 bpm and more during continuous insufflation than when gas was insufflated only during expiration. These results suggest that tracheal gas insufflation may reduce the risk of ventilation-induced lung disease in the newborn.
Keywords
Animals Disease Models, Animal Humans Infant, Newborn *Insufflation *Intermittent Positive-Pressure Ventilation Intubation, Intratracheal Rabbits Respiratory Distress Syndrome, Newborn/*therapy
Pubmed
Web of science
Create date
17/01/2008 15:56
Last modification date
20/08/2019 14:27
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