Gene-environment interactions of selected pharmacogenes in arterial hypertension.

Details

Serval ID
serval:BIB_6E38E7EB358C
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Gene-environment interactions of selected pharmacogenes in arterial hypertension.
Journal
Expert Review of Clinical Pharmacology
Author(s)
Bochud Murielle, Guessous Idris
ISSN
1751-2441 (Electronic)
ISSN-L
1751-2433
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
5
Number
6
Pages
677-686
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
Hypertension affects approximately 1 billion people worldwide. Owing to population aging, hypertension-related cardiovascular burden is expected to rise in the near future. In addition to genetic variants influencing the blood pressure response to antihypertensive drugs, several genes encoding for drug-metabolizing or -transporting enzymes have been associated with blood pressure and/or hypertension in humans (e.g., ACE, CYP1A2, CYP3A5, ABCB1 and MTHFR) regardless of drug treatment. These genes are also involved in the metabolism and transport of endogenous substances and their effects may be modified by selected environmental factors, such as diet or lifestyle. However, little is currently known on the complex interplay between environmental factors, endogenous factors, genetic variants and drugs on blood pressure control. This review will discuss the respective role of population-based primary prevention and personalized medicine for arterial hypertension, taking a pharmacogenomics' perspective focusing on selected pharmacogenes.
Pubmed
Web of science
Create date
27/12/2012 12:58
Last modification date
20/08/2019 14:27
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