EBV+ cutaneous B-cell lymphoproliferation of the leg in an elderly patient with mycosis fungoides and methotrexate treatment.

Details

Serval ID
serval:BIB_6E23C360E8C8
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
EBV+ cutaneous B-cell lymphoproliferation of the leg in an elderly patient with mycosis fungoides and methotrexate treatment.
Journal
Apmis : Acta Pathologica, Microbiologica, et Immunologica Scandinavica
Author(s)
Rausch T., Cairoli A., Benhattar J., Spring P., Hohl D., de Leval L.
ISSN
1600-0463 (Electronic)
ISSN-L
0903-4641
Publication state
Published
Issued date
2013
Volume
121
Number
1
Pages
79-84
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
A 77-year-old man with a 5-year history of mycosis fungoides (MF) who had received several lines of therapy, including intravenous courses of Methotrexate (MTX) for the past 2 years, went on to develop several ulcerated cutaneous nodules on the left leg. Biopsy revealed diffuse sheets of EBV-positive large B cells (CD20+ CD30 ± IgM Lambda), with an angiocentric distribution and a monoclonal IGH gene rearrangement. Although the pathological features were diagnostic for an EBV-positive diffuse large B-cell lymphoma (DLBCL), several possibilities could be considered for assignment to a specific entity: EBV-positive DLBCL of the elderly, methotrexate-induced lymphoproliferative disorder (LPD), lymphomatoid granulomatosis, or the more recently described EBV-positive mucocutaneous ulcer. The development of EBV+ lymphoproliferations has been reported in two other patients with MF under MTX, and occurred as skin lesions of the leg in one of these and in the current case, which may question the relatedness to primary cutaneous DLCBL, leg-type.
Pubmed
Web of science
Create date
21/02/2013 17:49
Last modification date
20/08/2019 14:27
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