Evidence of HLA class II association with antibody response against the malaria vaccine SPF66 in a naturally exposed population

Details

Serval ID
serval:BIB_6E172891B6B9
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Evidence of HLA class II association with antibody response against the malaria vaccine SPF66 in a naturally exposed population
Journal
American Journal of Tropical Medicine and Hygiène
Author(s)
Beck  H. P., Felger  I., Barker  M., Bugawan  T., Genton  B., Alexander  N., Jazwinska  E., Erlich  H., Alpers  M.
ISSN
0002-9637 (Print)
Publication state
Published
Issued date
09/1995
Volume
53
Number
3
Pages
284-8
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S. --- Old month value: Sep
Abstract
The antibody response against the malaria vaccine SPf66 and against circumsporozoite (CS) protein has been tested in immune adults from a malaria endemic area in Papua New Guinea. All individuals were genotyped for the HLA class II DQB1 and DRB1 loci, and the humoral response was analyzed with respect to the identified class II alleles. At each locus, only three alleles were frequent, namely DRB1*11, *15, and *16, and DQB1*0301, *0502, and *0601. Antibodies against SPf66 and CS protein were found in 84% and 79% of the individuals, respectively. A strong negative association was detected between the humoral response against SPf66 and DRB1*15 and DQB1*0601. A positive association of the response was observed with DRB1*11 and DQB1*0301. After analysis with a multiple regression model in which all alleles were included simultaneously, only DRB1*15 remained significantly associated with low antibody responses. This suggests that nonresponders may be expected after immunization with SPf66 in certain populations.
Keywords
Adolescent Adult Aged Animals Antibodies, Protozoan/*biosynthesis Base Sequence DNA Primers *Genes, MHC Class II Genotype HLA-DQ Antigens/genetics HLA-DR Antigens/genetics Humans Malaria Vaccines/*immunology Malaria, Falciparum/immunology/prevention & control Middle Aged Molecular Sequence Data Plasmodium falciparum/*immunology Polymorphism, Genetic Protozoan Proteins/*immunology *Recombinant Proteins Vaccines, Synthetic/*immunology
Pubmed
Web of science
Create date
28/01/2008 11:49
Last modification date
20/08/2019 14:27
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