Effect of CPAP during cardiopulmonary bypass on postoperative lung function. An experimental study

Details

Serval ID
serval:BIB_6E061718416D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effect of CPAP during cardiopulmonary bypass on postoperative lung function. An experimental study
Journal
Acta Anaesthesiologica Scandinavica
Author(s)
Magnusson  L., Zemgulis  V., Wicky  S., Tyden  H., Hedenstierna  G.
ISSN
0001-5172 (Print)
Publication state
Published
Issued date
11/1998
Volume
42
Number
10
Pages
1133-8
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Nov
Abstract
BACKGROUND: Respiratory failure secondary to cardiopulmonary bypass (CPB) remains a major complication after cardiac surgery. We tested the hypothesis that post-CPB lung function impairment can be prevented by continuous positive airway pressure (CPAP) applied during the CPB. METHODS: In 6 pigs, CPAP with 5 cmH2O pressure was applied during CPB. Six other pigs served as control, i.e. the lungs were open to the atmosphere during CPB. After median sternotomy, the right atrial appendage as well as the ascending aorta were cannulated. The total CPB duration was 90 min with 45 min cardioplegic arrest. Ventilation-perfusion distribution was measured with the multiple inert gas elimination technique and atelectasis by CT-scanning. RESULTS: Large atelectasis appeared after CPB, corresponding to 14.5% +/- 5.5 (percent of the total lung area) in the CPAP group and 18.7% +/- 5.2 in the controls (P = 0.20). Intrapulmonary shunt increased and PaO2 decreased after the CPB in both groups. CONCLUSIONS: We conclude that in this pig model post-CPB atelectasis is not effectively prevented by CPAP applied during CPB.
Keywords
Airway Resistance/physiology Analysis of Variance Animals Atelectasis/etiology/radiography Cardiac Output/physiology *Cardiopulmonary Bypass/adverse effects Heart Arrest, Induced Lung/*physiology Lung Compliance/physiology Oxygen/blood *Positive-Pressure Respiration Pulmonary Gas Exchange/physiology Random Allocation Respiratory Insufficiency/etiology/prevention & control Sternum/surgery Swine Thoracotomy Time Factors Tomography, X-Ray Computed Ventilation-Perfusion Ratio/physiology
Pubmed
Web of science
Create date
28/01/2008 10:51
Last modification date
20/08/2019 14:27
Usage data