MIBG scintigraphy for the diagnosis and follow-up of children with neuroblastoma.

Details

Serval ID
serval:BIB_6E035FBA8789
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
MIBG scintigraphy for the diagnosis and follow-up of children with neuroblastoma.
Journal
Quarterly Journal of Nuclear Medicine and Molecular Imaging
Author(s)
Boubaker A., Bischof Delaloye A.
ISSN
1824-4785 (Print)
ISSN-L
1824-4785
Publication state
Published
Issued date
2008
Volume
52
Number
4
Pages
388-402
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Neuroblastoma (NBL) is the commonest extra-cranial solid tumor in children and the leading cause of cancer related deaths in childhood between the age of 1 to 4 years. NBL may behave in very different ways, from the less aggressive stage 4S NBL or congenital forms that may resolve without treatment in up to 90% of the children, to the high-risk disseminated stage 4 disease in older children with a cure rate of 35 to 40%. Initial staging is crucial for effective management and radiolabeled metaiodobenzylguanidine (MIBG) with iodine-123 is a powerful tool with a sensitivity around 90% and a specificity close to 100% for the diagnosis of NBL. MIBG scintigraphy is used routinely and is mandatory in most investigational clinical trials both for the initial staging of the disease, the evaluation of the response to treatment, as well as for the detection of recurrence during follow-up. With respect to outcome of children presenting disseminated stage 4 NBL, the role of post-therapeutic [(123)I]MIBG scan has been investigated by several groups but so far there is no consensus whereas a complete or very good partial response as assessed by MIBG may be of prognostic value. NBL needs a multimodality approach at diagnosis and during follow-up and MIBG scintigraphy keeps its pivotal role, in particular with respect to bone marrow involvement and/or cortical bone metastases.
Keywords
3-Iodobenzylguanidine/diagnostic use, Child, Follow-Up Studies, Humans, Neuroblastoma/genetics, Neuroblastoma/pathology, Risk
Pubmed
Web of science
Create date
16/01/2009 17:32
Last modification date
20/08/2019 14:27
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