Syndrome HNPCC (hereditary non polyposis colon cancer)--notions de base et considérations éthiques [Hereditary non polyposis colon cancer--basic principle and ethical considerations]

Details

Serval ID
serval:BIB_6DFB21E28A9E
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Syndrome HNPCC (hereditary non polyposis colon cancer)--notions de base et considérations éthiques [Hereditary non polyposis colon cancer--basic principle and ethical considerations]
Journal
Revue Médicale Suisse
Author(s)
Bouzourene  H., Monnerat  C.
ISSN
1660-9379 (Print)
Publication state
Published
Issued date
2005
Volume
1
Number
43
Pages
2791-2797
Notes
PT - English Abstract PT - Journal Article
Abstract
HNPCC is a hereditary cancer syndrome of several organs but more particularly the colon and the uterus. It is characterized by microsatellite instability (MSI) related to mutations of DNA mismatch repair (MMR) genes. The role of the pathologist in the detection of colorectal cancer with MSI phenotype is important. Among the available tests to detect MSI, immunohistochemistry appears being a sensitive, specific and inexpensive test. The detection of HNPCC syndrome by the genetic test among the MSI cancers implies a coordination of the structures of health and requires a follow-up of the patients, during and after the genetic test. Ethical dimension related to these hereditary cancers must be considered without constituting a brake for their detection
Keywords
Colorectal Neoplasms,Hereditary Nonpolyposis/diagnosis/Ethics,Medical/Genetic Predisposition to Disease/Genetic Screening/ethics/Humans/Immunohistochemistry/Phenotype/Syndrome/Colon
Pubmed
Create date
29/01/2008 18:34
Last modification date
20/08/2019 14:27
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