Functional immunity against SARS-CoV-2 in the general population after a booster campaign and the Delta and Omicron waves, Switzerland, March 2022.

Amati, R.; Frei, A.; Kaufmann, M.; Sabatini, S.; Pellaton, C.; Fehr, J.; Albanese, E.; Puhan, M.A.

doi:10.2807/1560-7917.ES.2022.27.31.2200561

Functional immunity against SARS-CoV-2 in the general population after a booster campaign and the Delta and Omicron waves, Switzerland, March 2022.

Details

Download: 35929427_BIB_6DDFE21CA95A.pdf (290.83 [Ko])
State: Public
Version: Final published version
License: CC BY 4.0

Serval ID

serval:BIB_6DDFE21CA95A

Type

Article: article from journal or magazin.

Collection

Publications

Institution

UNIL/CHUV

Title

Functional immunity against SARS-CoV-2 in the general population after a booster campaign and the Delta and Omicron waves, Switzerland, March 2022.

Journal

Euro surveillance

Author(s)

Amati R., Frei A., Kaufmann M., Sabatini S., Pellaton C., Fehr J., Albanese E., Puhan M.A.

Working group(s)

Corona Immunitas Research Group

Contributor(s)

Bochud Murielle , Bodenmann Patrick , Butty Audrey , D'Acremont Valérie , Duperrex Olivier , Dupraz Julien , Egger Malik , Estoppey Sandrine , Faivre Vincent , Felappi Andrea , Fenwick Craig , Gonseth Nusslé Semira , Jendly Emilie , Pantaleo Giuseppe , Pasquier Jérôme , Pellaton Céline , Sanchis Zozaya Javier , Schlüter Virginie , Steiner-Dubuis Amélie , Thabard Julien , Vassaux Sophie , Zuppinger Claire

ISSN

1560-7917 (Electronic)

ISSN-L

1025-496X

Publication state

Published

Issued date

08/2022

Peer-reviewed

Oui

Volume

Number

Language

english

Notes

Publication types: Journal Article
Publication Status: ppublish

Abstract

Functional immunity (defined here as serum neutralising capacity) critically contributes to conferring protection against SARS-CoV-2 infection and severe COVID-19. This cross-sectional analysis of a prospective, population-based cohort study included 1,894 randomly-selected 16 to 99-year-old participants from two Swiss cantons in March 2022. Of these, 97.6% (95% CI: 96.8-98.2%) had anti-spike IgG antibodies, and neutralising capacity was respectively observed for 94%, 92% and 88% against wild-type SARS-CoV-2, Delta and Omicron variants. Studying functional immunity to inform and monitor vaccination campaigns is crucial.

Keywords

Adolescent, Adult, Aged, Aged, 80 and over, Antibodies, Neutralizing, Antibodies, Viral, COVID-19/immunology, COVID-19/prevention & control, COVID-19 Vaccines/administration & dosage, Cross-Sectional Studies, Humans, Immunization Programs, Immunization, Secondary, Middle Aged, Prospective Studies, SARS-CoV-2, Spike Glycoprotein, Coronavirus/immunology, Switzerland/epidemiology, Young Adult, neutralising activity, seroprevalence, variants of concern

URN

urn:nbn:ch:serval-BIB_6DDFE21CA95A1

OAI-PMH

oai:serval.unil.ch:BIB_6DDFE21CA95A

DOI

10.2807/1560-7917.ES.2022.27.31.2200561

Pubmed

35929427

Web of science

000888471600003

Open Access

Yes