Angiotensin II antagonists DuP 753 and TCV 116.

Details

Serval ID
serval:BIB_6DD65AD72B24
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Angiotensin II antagonists DuP 753 and TCV 116.
Journal
Journal of Hypertension. Supplement
Author(s)
Brunner H.R., Delacrétaz E., Nussberger J., Burnier M., Waeber B.
ISSN
0952-1178
Publication state
Published
Issued date
1994
Volume
12
Number
9
Pages
S29-34
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review - Publication Status: ppublish
Abstract
BACKGROUND: Acute blockade of the renin-angiotensin system with the parenterally active angiotensin II antagonist saralasin has been shown to effectively lower blood pressure in a large fraction of patients with essential hypertension and to improve haemodynamics in some patients with congestive heart failure. It is now possible to chronically antagonize angiotensin II at its receptor using non-peptide angiotensin II inhibitors such as losartan (DuP 753/MK-954) or TCV 116. EFFECT OF NON-PEPTIDE ANGIOTENSIN II ANTAGONISTS: When administered by mouth, DuP 753 and TCV 116 induce dose-dependent inhibition of the pressor response to exogenous angiotensin II. This effect is closely related to circulating levels of the corresponding active metabolites E3174 and CV11974. Preliminary studies performed in hypertensive patients suggest that losartan lowers blood pressure to an equivalent extent to an angiotensin converting enzyme (ACE) inhibitor. CONCLUSIONS: Further investigation is required to show whether these new angiotensin II antagonists compounds compare favourably with ACE inhibitors.
Keywords
Administration, Oral, Angiotensin II, Benzimidazoles, Biphenyl Compounds, Blood Pressure, Dose-Response Relationship, Drug, Humans, Hypertension, Imidazoles, Losartan, Renin-Angiotensin System, Tetrazoles
Pubmed
Web of science
Create date
25/01/2008 13:55
Last modification date
20/08/2019 15:27
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