Anti-inflammatoires non stéroïdiens (AINS) et inflammation oculaire [Non-steroidal anti-inflammatory drugs and ocular inflammation]

Details

Serval ID
serval:BIB_6DD4E3207FAB
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Anti-inflammatoires non stéroïdiens (AINS) et inflammation oculaire [Non-steroidal anti-inflammatory drugs and ocular inflammation]
Journal
Klinische Monatsblatter fur Augenheilkunde
Author(s)
Guex-Crosier Y.
ISSN
0023-2165 (Print)
ISSN-L
0023-2165
Publication state
Published
Issued date
05/2001
Peer-reviewed
Oui
Volume
218
Number
5
Pages
305-308
Language
french
Notes
Publication types: English Abstract ; Journal Article
Publication Status: ppublish
Abstract
Ocular inflammation is regulated by complicated mechanism that are responsible for the rupture of the blood-ocular barrier and the attraction of leukocytes towards the eye. This cellular trafficking is regulated by the liberation of inflammatory mediators and cytokines.
The main effects of prostaglandins that are described in the literature were reviewed.
Despite the fact that the inhibitory action of aspirin and NSAIDs on prostaglandins secretion is known since 1971, it is quite recently that two isoenzymes of cyclooxygenase were discovered. The Cyclooxygenase-1 (COX-1) is constitutive and is responsible for the production of PGE2. This prostaglandin is related to the housekeeping functions such as gastric protection, platelet aggregation and maintenance of renal function. The expression of the cyclooxygenase 2 (COX-2) is induced by inflammation. The presence of COX-2 could be demonstrated in many ocular tissues (corneal epithelium and endothelium, pigmentary epithelium etc. ...). The use of NSAIDs in clinical practice allows a good control of ocular inflammation, of pain, of the maintenance of a good mydriasis during surgery and are impending the onset of postoperative cystoid macular edema.
Prostaglandins are potent anti-inflammatory agents but their use is limited in the presence of severe dry eye syndrome or allergy towards NSAIDs.
Keywords
Anti-Inflammatory Agents, Non-Steroidal/adverse effects, Anti-Inflammatory Agents, Non-Steroidal/therapeutic use, Blood-Retinal Barrier/drug effects, Blood-Retinal Barrier/immunology, Endophthalmitis/drug therapy, Endophthalmitis/immunology, Humans, Immune Tolerance/drug effects, Inflammation Mediators/antagonists & inhibitors, Inflammation Mediators/physiology, Leukocytes/drug effects, Leukocytes/immunology, Macular Edema/drug therapy, Macular Edema/immunology
Pubmed
Web of science
Create date
28/01/2008 12:45
Last modification date
15/10/2020 5:23
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