Major histocompatibility complex class I-dependent skewing of the natural killer cell Ly49 receptor repertoire.

Details

Serval ID
serval:BIB_6DBBBA94935C
Type
Article: article from journal or magazin.
Collection
Publications
Title
Major histocompatibility complex class I-dependent skewing of the natural killer cell Ly49 receptor repertoire.
Journal
European journal of immunology
Author(s)
Held W., Dorfman J.R., Wu M.F., Raulet D.H.
ISSN
0014-2980
Publication state
Published
Issued date
1996
Peer-reviewed
Oui
Volume
26
Number
10
Pages
2286-2210.1002/eji.183026100392
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
Publication Status: ppublish
Abstract
Subsets of mouse natural killer (NK) cells express receptors encoded by the Ly49 gene family that recognize allelic determinants on major histocompatibility complex (MHC) class I molecules. Recognition of self class I molecules typically inhibits NK cell lytic function. The presence of NK cell subsets expressing receptors which are able to discriminate class I alleles raises the possibility that there exist mechanisms to coordinate the NK cell receptor repertoire with the class I molecules of the host. In the present study, we determined the effects of class I gene expression on the frequencies of NK cells expressing three different Ly49 receptors defined by monoclonal antibodies. We show here an MHC-dependent skewing of NK cell subsets expressing multiple Ly49 receptors with specificity for self MHC. The results provide the first evidence that the frequencies of NK cells expressing different Ly49 receptors are determined by the host's MHC molecules. The results also extend previous findings that MHC class I expression influences the cell surface levels of each Ly49 receptor, suggesting an additional mechanism by which MHC molecules may influence the effective specificity of NK cells. Models to account for self tolerance and MHC-controlled repertoire differences are discussed.
Keywords
Animals, Antigens, Ly, Genes, MHC Class I, Histocompatibility Antigens Class I/physiology, Immunity, Cellular, Killer Cells, Natural/physiology, Lectins, C-Type, Lymphocyte Subsets/physiology, Membrane Glycoproteins/physiology, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Receptors, Immunologic/physiology, Receptors, NK Cell Lectin-Like, Spleen/cytology
Pubmed
Web of science
Create date
17/01/2008 15:24
Last modification date
20/08/2019 14:27
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