Investigation of gene-environment interactions in relation to tic severity.
Details
Serval ID
serval:BIB_6D97CD3D1149
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Investigation of gene-environment interactions in relation to tic severity.
Journal
Journal of neural transmission
ISSN
1435-1463 (Electronic)
ISSN-L
0300-9564
Publication state
Published
Issued date
11/2021
Peer-reviewed
Oui
Volume
128
Number
11
Pages
1757-1765
Language
english
Notes
Publication types: Journal Article ; Meta-Analysis
Publication Status: ppublish
Publication Status: ppublish
Abstract
Tourette syndrome (TS) is a neuropsychiatric disorder with involvement of genetic and environmental factors. We investigated genetic loci previously implicated in Tourette syndrome and associated disorders in interaction with pre- and perinatal adversity in relation to tic severity using a case-only (N = 518) design. We assessed 98 single-nucleotide polymorphisms (SNPs) selected from (I) top SNPs from genome-wide association studies (GWASs) of TS; (II) top SNPs from GWASs of obsessive-compulsive disorder (OCD), attention-deficit/hyperactivity disorder (ADHD), and autism spectrum disorder (ASD); (III) SNPs previously implicated in candidate-gene studies of TS; (IV) SNPs previously implicated in OCD or ASD; and (V) tagging SNPs in neurotransmitter-related candidate genes. Linear regression models were used to examine the main effects of the SNPs on tic severity, and the interaction effect of these SNPs with a cumulative pre- and perinatal adversity score. Replication was sought for SNPs that met the threshold of significance (after correcting for multiple testing) in a replication sample (N = 678). One SNP (rs7123010), previously implicated in a TS meta-analysis, was significantly related to higher tic severity. We found a gene-environment interaction for rs6539267, another top TS GWAS SNP. These findings were not independently replicated. Our study highlights the future potential of TS GWAS top hits in gene-environment studies.
Keywords
Attention Deficit Disorder with Hyperactivity/genetics, Autism Spectrum Disorder/genetics, Female, Gene-Environment Interaction, Genome-Wide Association Study, Humans, Pregnancy, Severity of Illness Index, Tics, Tourette Syndrome, Gene–environment interaction, Pre- and perinatal complications, Tic severity, Tourette syndrome
Pubmed
Web of science
Open Access
Yes
Create date
12/11/2021 15:57
Last modification date
12/01/2022 8:10