Investigation of gene-environment interactions in relation to tic severity.

Details

Ressource 1Download: 34389898_BIB_6D97CD3D1149.pdf (624.32 [Ko])
State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_6D97CD3D1149
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Investigation of gene-environment interactions in relation to tic severity.
Journal
Journal of neural transmission
Author(s)
Abdulkadir M., Yu D., Osiecki L., King R.A., Fernandez T.V., Brown L.W., Cheon K.A., Coffey B.J., Garcia-Delgar B., Gilbert D.L., Grice D.E., Hagstrøm J., Hedderly T., Heyman I., Hong H.J., Huyser C., Ibanez-Gomez L., Kim Y.K., Kim Y.S., Koh Y.J., Kook S., Kuperman S., Leventhal B., Madruga-Garrido M., Maras A., Mir P., Morer A., Münchau A., Plessen K.J., Roessner V., Shin E.Y., Song D.H., Song J., Visscher F., Zinner S.H., Mathews C.A., Scharf J.M., Tischfield J.A., Heiman G.A., Dietrich A., Hoekstra P.J.
ISSN
1435-1463 (Electronic)
ISSN-L
0300-9564
Publication state
Published
Issued date
11/2021
Peer-reviewed
Oui
Volume
128
Number
11
Pages
1757-1765
Language
english
Notes
Publication types: Journal Article ; Meta-Analysis
Publication Status: ppublish
Abstract
Tourette syndrome (TS) is a neuropsychiatric disorder with involvement of genetic and environmental factors. We investigated genetic loci previously implicated in Tourette syndrome and associated disorders in interaction with pre- and perinatal adversity in relation to tic severity using a case-only (N = 518) design. We assessed 98 single-nucleotide polymorphisms (SNPs) selected from (I) top SNPs from genome-wide association studies (GWASs) of TS; (II) top SNPs from GWASs of obsessive-compulsive disorder (OCD), attention-deficit/hyperactivity disorder (ADHD), and autism spectrum disorder (ASD); (III) SNPs previously implicated in candidate-gene studies of TS; (IV) SNPs previously implicated in OCD or ASD; and (V) tagging SNPs in neurotransmitter-related candidate genes. Linear regression models were used to examine the main effects of the SNPs on tic severity, and the interaction effect of these SNPs with a cumulative pre- and perinatal adversity score. Replication was sought for SNPs that met the threshold of significance (after correcting for multiple testing) in a replication sample (N = 678). One SNP (rs7123010), previously implicated in a TS meta-analysis, was significantly related to higher tic severity. We found a gene-environment interaction for rs6539267, another top TS GWAS SNP. These findings were not independently replicated. Our study highlights the future potential of TS GWAS top hits in gene-environment studies.
Keywords
Attention Deficit Disorder with Hyperactivity/genetics, Autism Spectrum Disorder/genetics, Female, Gene-Environment Interaction, Genome-Wide Association Study, Humans, Pregnancy, Severity of Illness Index, Tics, Tourette Syndrome, Gene–environment interaction, Pre- and perinatal complications, Tic severity, Tourette syndrome
Pubmed
Web of science
Open Access
Yes
Create date
12/11/2021 15:57
Last modification date
12/01/2022 8:10
Usage data