Modulation of collagen synthesis in normal and osteoarthritic cartilage.

Details

Serval ID
serval:BIB_6D941D35E500
Type
Article: article from journal or magazin.
Collection
Publications
Title
Modulation of collagen synthesis in normal and osteoarthritic cartilage.
Journal
Biorheology
Author(s)
Gouttenoire J., Valcourt U., Ronzière M.C., Aubert-Foucher E., Mallein-Gerin F., Herbage D.
ISSN
0006-355X (Print)
ISSN-L
0006-355X
Publication state
Published
Issued date
2004
Volume
41
Number
3-4
Pages
535-542
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
In osteoarthritic cartilage, chondrocytes are able to present heterogeneous cellular reactions with expression and synthesis of the (pro)collagen types characteristic of prechondrocytes (type IIA), hypertrophic chondrocytes (type X), as well as differentiated (types IIB, IX, XI, VI) and dedifferentiated (types I, III) chondrocytes. The expression of type IIA procollagen in human osteoarthritic cartilage support the assumption that OA chondrocytes reverse their phenotype towards a chondroprogenitor phenotype. Recently, we have shown that dedifferentiation of mouse chondrocytes induced by subculture was associated with the alternative splicing of type II procollagen pre-mRNA with a switch from the IIB to the IIA form. In this context, we demonstrated that BMP-2 favours expression of type IIB whereas TGF-beta1 potentiates expression of type IIA induced by subculture. These data reveal the specific capability of BMP-2 to reverse the program of chondrocyte dedifferentiation. This interesting feature needs to be tested with human chondrocytes since cell amplification is required for the currently used autologous chondrocyte transplantation.
Keywords
Animals, Bone Morphogenetic Protein 2, Bone Morphogenetic Proteins/pharmacology, Cartilage, Articular, Cell Differentiation/drug effects, Cells, Cultured, Chondrocytes/metabolism, Collagen/biosynthesis, Extracellular Matrix/metabolism, Humans, Osteoarthritis/metabolism, Procollagen/metabolism, Transforming Growth Factor beta/pharmacology
Pubmed
Create date
01/10/2015 15:27
Last modification date
20/08/2019 14:27
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