The lateral habenula in addiction and depression: an anatomical, synaptic and behavioral overview.

Details

Serval ID
serval:BIB_6D9401C58D2D
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
The lateral habenula in addiction and depression: an anatomical, synaptic and behavioral overview.
Journal
European Journal of Neuroscience
Author(s)
Lecca S., Meye F.J., Mameli M.
ISSN
1460-9568 (Electronic)
ISSN-L
0953-816X
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
39
Number
7
Pages
1170-1178
Language
english
Abstract
The lateral habenula (LHb) is an epithalamic region with a crucial role in the regulation of midbrain monoaminergic systems. Over the past few years a renewed interest in the LHb has emerged due to studies highlighting its central role in encoding rewarding and aversive aspects of stimuli. Moreover, an increasing number of functional as well as behavioral indications provide substantial evidence supporting a role of LHb in neuropsychiatric diseases, including mood disorders and drug addiction. Cellular and synaptic adaptations in the LHb may therefore represent a critical phenomenon in the etiology of these diseases. In the current review we describe the anatomical and functional connections allowing the LHb to control the dopamine and serotonin systems, as well as possible roles of these connections in motivated behaviors and neuropsychiatric disorders. Finally, we discuss how drug exposure and stressful conditions alter the cellular physiology of the LHb, highlighting a role for the LHb in the context of drug addiction and depression.

Keywords
Animals, Depressive Disorder/metabolism, Depressive Disorder/physiopathology, Dopamine/metabolism, Habenula/metabolism, Habenula/pathology, Habenula/physiopathology, Humans, Serotonin/metabolism, Substance-Related Disorders/metabolism, Substance-Related Disorders/physiopathology, Synapses/metabolism, Synapses/physiology, Synaptic Transmission
Pubmed
Web of science
Create date
31/01/2017 15:59
Last modification date
20/08/2019 15:27
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