Genetic immune and inflammatory markers associated with diabetes in solid organ transplant recipients.

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Serval ID
serval:BIB_6D920C4CDD77
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Genetic immune and inflammatory markers associated with diabetes in solid organ transplant recipients.
Journal
American journal of transplantation
Author(s)
Quteineh L., Wójtowicz A., Bochud P.Y., Crettol S., Vandenberghe F., Venetz J.P., Manuel O., Golshayan D., Lehmann R., Mueller N.J., Binet I., van Delden C., Steiger J., Mohacsi P., Dufour J.F., Soccal P.M., Kutalik Z., Marques-Vidal P., Vollenweider P., Recher M., Hess C., Pascual M., Eap C.B.
Working group(s)
Swiss Transplant Cohort Study
ISSN
1600-6143 (Electronic)
ISSN-L
1600-6135
Publication state
Published
Issued date
01/2019
Peer-reviewed
Oui
Volume
19
Number
1
Pages
238-246
Language
english
Notes
Publication types: Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
New-onset diabetes mellitus after transplantation (NODAT) is a complication following solid organ transplantation (SOT) and may be related to immune or inflammatory responses. We investigated whether single nucleotide polymorphisms (SNPs) within 158 immune- or inflammation-related genes contribute to NODAT in SOT recipients. The association between 263 SNPs and NODAT was investigated in a discovery sample of SOT recipients from the Swiss Transplant Cohort Study (STCS, n <sub>1</sub> = 696). Positive results were tested in a first STCS replication sample (n <sub>2</sub> = 489) and SNPs remaining significant after multiple test corrections were tested in a second SOT replication sample (n <sub>3</sub> = 156). Associations with diabetic traits were further tested in several large general population-based samples (n > 480 000). Only SP110 rs2114592C>T remained associated with NODAT in the STCS replication sample. Carriers of rs2114592-TT had 9.9 times (95% confidence interval [CI]: 3.22-30.5, P = .00006) higher risk for NODAT in the combined STCS samples (n = 1184). rs2114592C>T was further associated with NODAT in the second SOT sample (odds ratio: 4.8, 95% CI: 1.55-14.6, P = .006). On the other hand, SP110 rs2114592C>T was not associated with diabetic traits in population-based samples, suggesting a specific gene-environment interaction, possibly due to the use of specific medications (ie, immunosuppressants) in transplant patients and/or to the illness that may unmask the gene effect.
Keywords
Adolescent, Adult, Aged, Diabetes Mellitus/etiology, Diabetes Mellitus/genetics, Diabetes Mellitus/immunology, Female, Gene-Environment Interaction, Heterozygote, Homozygote, Humans, Immunosuppression, Immunosuppressive Agents/therapeutic use, Inflammation/genetics, Inflammation/immunology, Male, Middle Aged, Odds Ratio, Organ Transplantation, Polymorphism, Single Nucleotide, Prospective Studies, Switzerland/epidemiology, Transplant Recipients, Young Adult, clinical research/practice, diabetes, genetics, new onset/posttransplant
Pubmed
Web of science
Open Access
Yes
Create date
28/06/2018 9:50
Last modification date
27/04/2020 6:20
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