A mouse model for hepatitis E virus infection.

Details

Serval ID
serval:BIB_6D7E80AC7E80
Type
Article: article from journal or magazin.
Publication sub-type
Editorial
Collection
Publications
Title
A mouse model for hepatitis E virus infection.
Journal
Journal of Hepatology
Author(s)
Gouttenoire J., Moradpour D.
ISSN
1600-0641 (Electronic)
ISSN-L
0168-8278
Publication state
Published
Issued date
2016
Peer-reviewed
Oui
Volume
64
Number
5
Pages
1003-1005
Language
english
Abstract
Leishmania parasites cause a broad range of disease, with cutaneous afflictions being, by far, the most prevalent. Variations in disease severity and symptomatic spectrum are mostly associated to parasite species. One risk factor for the severity and emergence of leishmaniasis is immunosuppression, usually arising by coinfection of the patient with human immunodeficiency virus (HIV). Interestingly, several species of Leishmania have been shown to bear an endogenous cytoplasmic dsRNA virus (LRV) of the Totiviridae family, and recently we correlated the presence of LRV1 within Leishmania parasites to an exacerbation murine leishmaniasis and with an elevated frequency of drug treatment failures in humans. This raises the possibility of further exacerbation of leishmaniasis in the presence of both viruses, and here we report a case of cutaneous leishmaniasis caused by Leishmania braziliensis bearing LRV1 with aggressive pathogenesis in an HIV patient. LRV1 was isolated and partially sequenced from skin and nasal lesions. Genetic identity of both sequences reinforced the assumption that nasal parasites originate from primary skin lesions. Surprisingly, combined antiretroviral therapy did not impact the devolution of Leishmania infection. The Leishmania infection was successfully treated through administration of liposomal amphotericin B.
Keywords
Animals, Disease Models, Animal, Hepatitis B virus, Hepatitis E, Hepatitis E virus, Humans, Mice
Pubmed
Web of science
Create date
16/02/2016 18:23
Last modification date
20/08/2019 15:27
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