Fate of cadmium in rat renal tubules: a micropuncture study.
Details
Serval ID
serval:BIB_6D706FB1CA1C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Fate of cadmium in rat renal tubules: a micropuncture study.
Journal
Toxicology and Applied Pharmacology
ISSN
0041-008X (Print)
ISSN-L
0041-008X
Publication state
Published
Issued date
1989
Peer-reviewed
Oui
Volume
98
Number
2
Pages
243-251
Language
english
Abstract
Free-flow micropuncture was carried out in superficial nephrons of Munich-Wistar type rats infused acutely with Cd acetate (CdA) or Cd-DTPA (141 microM Cd). Fluid obtained from Bowman's space (BS) or end-proximal tubule sites was analyzed for Cd and inulin. The fluid/plasma Cd concentration ratio in BS averaged 0.2 and 1.0 during CdA and Cd-DTPA infusions, respectively. End-proximal tubule fractional excretion of Cd during CdA infusion averaged 0.34. Previous administration of CdA (1.0 mg/kg, 48 hr before micropuncture) increased the level of circulating Cd-metallothioneins, as measured by radioimmunoassay, but did not affect the luminal tubular uptake of Cd during CdA infusion. No net transepithelial movement of Cd-DTPA was measured. It is concluded that Cd ultrafiltered during inorganic Cd administration is taken up to a large extent by the convoluted part of proximal tubules.
Keywords
Animals, Cadmium/pharmacokinetics, Female, Immunization, Kidney Tubules/metabolism, Metallothionein/analysis, Metallothionein/metabolism, Punctures, Radioimmunoassay, Rats, Ultrafiltration
Pubmed
Web of science
Create date
21/01/2008 12:54
Last modification date
20/08/2019 15:27