The osteoprotegerin/RANK/RANKL system: a bone key to vascular disease.

Details

Serval ID
serval:BIB_6D6F64B42665
Type
Article: article from journal or magazin.
Collection
Publications
Title
The osteoprotegerin/RANK/RANKL system: a bone key to vascular disease.
Journal
Journal of endocrinological investigation
Author(s)
D'Amelio P., Isaia G., Isaia G.C.
ISSN
0391-4097 (Print)
ISSN-L
0391-4097
Publication state
Published
Issued date
2009
Peer-reviewed
Oui
Volume
32
Number
4 Suppl
Pages
6-9
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
Osteoporosis and atherosclerosis are degenerative disorders of old age that often present together, but recently it has been suggested that the association between osteoporosis and cardio-vascular diseases is not just due to the aging process. The osteoprotegerin (OPG)/receptor activator of nuclear factor-kB (RANK)/RANK ligand (RANKL) system has been identified as a possible mediator of arterial calcification suggesting common links between osteoporosis and vascular diseases. Since the discovery of the OPG/RANK/RANKL system, much has been learned about its role in controlling skeletal biology; however, its role in the context of vascular biology is only beginning to be explored. It has been suggested that OPG might act as an autocrine/paracrine regulator of vascular calcification and might be useful as a serum marker of vascular disease. However, the exact role of OPG (or RANKL/RANK) in vascular calcification is still not completely understood. This review aims to report the recent findings on the relationship between osteoporosis and OPG/RANK/RANKL-mediated vascular disease.
Keywords
Animals, Bone and Bones/metabolism, Calcinosis/etiology, Calcinosis/metabolism, Humans, Osteoprotegerin/metabolism, Osteoprotegerin/physiology, RANK Ligand/metabolism, RANK Ligand/physiology, Receptor Activator of Nuclear Factor-kappa B/metabolism, Receptor Activator of Nuclear Factor-kappa B/physiology, Signal Transduction/physiology, Vascular Diseases/etiology, Vascular Diseases/metabolism
Pubmed
Create date
16/01/2020 14:26
Last modification date
17/01/2020 6:26
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