Partial denervation of the whiskerpad in adult mice: altered patterns of metabolic activity in barrel cortex.

Details

Serval ID
serval:BIB_6D635DC442C4
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Partial denervation of the whiskerpad in adult mice: altered patterns of metabolic activity in barrel cortex.
Journal
European Journal of Neuroscience
Author(s)
Bronchti G., Corthésy M.E., Welker E.
ISSN
0953-816X
Publication state
Published
Issued date
08/1999
Peer-reviewed
Oui
Volume
11
Number
8
Pages
2847-2855
Language
english
Abstract
One hundred days after unilateral C-row nerve transection in the adult mouse whiskerpad, the caudal follicles of row C are reinnervated with approximately 80 % of the original number of axons [Corthésy, M.-E., Bronchti, G. & Welker, E. (1999) Eur. J. Neurosci. , 11, 2835-2846]. To what extent is this reinnervation functional, and how does it interact with the enlargement of the functional representation of neighbouring rows subsequent to the denervation? Using the autoradiographic deoxyglucose method, we studied the whisker representation at the level of the barrel cortex 100 days post lesionem. We stimulated whiskers belonging to the denervated row C, the neighbouring rows B and D, or to all five rows A-E. The deoxyglucose uptake was measured in tangential sections through layer IV. The results indicate that, 100 days post lesionem, whiskers of row C reactivate their cortical barrels. However, (i) the magnitude of this cortical response was reduced; (ii) row C barrels were equivalently activated by the stimulation of the neighbouring rows; and (iii) when all whiskers were stimulated, we observed a significantly reduced deoxyglucose uptake over the representation of nonlesioned whiskers of rows D and E. Therefore, 100 days after the peripheral nerve lesion the reinnervation of the whiskerpad had not restored a normal pattern of activation at the level of the barrel cortex. We propose that this is due to a modified interaction between the representations of the various rows of follicles at the cortical level that does not return to normal.
Keywords
Animals, Denervation, Deoxyglucose/pharmacokinetics, Mice, Mice, Inbred ICR, Nerve Regeneration/physiology, Nervous System Physiological Phenomena, Neuronal Plasticity/physiology, Physical Stimulation, Reference Values, Somatosensory Cortex/physiology, Vibrissae/innervation
Pubmed
Web of science
Create date
24/01/2008 14:41
Last modification date
20/08/2019 14:27
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