Atria assist device to restore transport function of fibrillating atrium

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Serval ID
serval:BIB_6D34476FA759
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Atria assist device to restore transport function of fibrillating atrium
Journal
European Journal of Cardio-Thoracic Surgery
Author(s)
Tozzi  P., Hayoz  D., Thevenaz  P., Roulet  J. Y., Salchli  F., von Segesser  L. K.
ISSN
1010-7940
Publication state
Published
Issued date
02/2008
Peer-reviewed
Oui
Volume
33
Number
2
Pages
263-267
Language
english
Notes
Journal Article --- Old month value: Feb
Abstract
Objective: The Maze procedure can restore sinus rhythm in patients suffering from chronic atrial fibrillation but often fails to restore the mechanical function of the atrium, the so-called atrial kick and requires long-term anticoagulation most of the time. A micro motorless pump (Atripump) based on artificial muscle technology positioned on the external surface of the atrium could compress the heart chamber, restoring atrium transport function. A bench model reproducing the mechanical function of human atrium and human environment has been developed to assess the circulatory support that such a pump can provide. Methods: Atripump (Nanopowers SA, Switzerland) is a dome-shape, silicone-coated nitinol actuator to be sutured on the external surface of the atrium. A pacemaker-like control unit drives the actuator and manages the external compression of the atrium. The bench model consists of an open circuit made of rubber bladder, 60cc in volume, connected to a vertically positioned and scaled tube that is filled at different levels reproducing changes in cardiac pre-load and after-load. The pump was placed on the outer surface of the bladder and both were immersed in water having a constant temperature of 37 degrees C. Pressure, volume and temperature at the interface dome-bladder were recorded. Results: Pump ran 24h for three consecutive months. During the experiment, no technical failure occurred and the pressure and volume values were repeatable during the experience. Nitinol fatigue was assessed measuring the wire's electric resistance that remained 400+/-10Omega/m. Contraction rate was 1Hz with power supply of 12V, 400m and heating time of 300ms. Pre-load ranged from 11 to 15mmHg. When inserted in the bath at 37+/-0.5 degrees C, maximal temperature between silicone membrane and rubber bladder was 39 degrees C. Maximal volume pumped was 492ml/min. Conclusions: This artificial muscle pump can reproduce the mechanical effect of a normal human atrium. It is compact, reliable and follows the Starling law. The surface temperature is in the physiologic range and it could represent a new tool to restore the atrial kick in persistent atrial fibrillation.
Pubmed
Web of science
Open Access
Yes
Create date
14/02/2008 14:15
Last modification date
25/09/2019 6:09
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