Alterations in airway inflammation and lung function during corticosteroid therapy for atopic asthma.

Details

Serval ID
serval:BIB_6D2374A6773D
Type
Article: article from journal or magazin.
Collection
Publications
Title
Alterations in airway inflammation and lung function during corticosteroid therapy for atopic asthma.
Journal
Chest
Author(s)
Faul J. L., Demers E. A., Burke C. M., Poulter L. W.
ISSN
0012-3692 (Print)
ISSN-L
0012-3692
Publication state
Published
Issued date
05/2002
Peer-reviewed
Oui
Volume
121
Number
5
Pages
1414-1420
Language
english
Abstract
Although corticosteroid therapy for asthma improves lung function and reduces airway inflammation, the relation between these two events is unclear. This article investigates associations between changes in bronchial inflammation and lung function during high-dose inhaled corticosteroid therapy for asthma.
Nine subjects with atopic asthma received high-dose inhaled fluticasone propionate (FP), 2,000 microg/d for 8 weeks. Fiberoptic bronchoscopy with endobronchial biopsies, spirometry, and histamine provocation challenge were performed on each subject at baseline, after 2 weeks, and again after 8 weeks of therapy. Spearman rank correlation coefficients between changes in parameters of bronchial inflammation and lung function were computed.
As expected, significant down-regulation of airway inflammation and improvements in lung function were observed after both short-term and long-term therapy with high-dose inhaled FP. During corticosteroid therapy, changes in lymphocyte and macrophage numbers in bronchial biopsy specimens were closely correlated. Changes in EG1+ eosinophils were associated with changes in EG2+ eosinophils after 8 weeks of therapy. Although changes in airway inflammation and changes in lung function were not closely associated after 2 weeks of therapy, changes in eosinophils (EG1) in bronchial biopsy specimens correlated with changes in bronchodilator response (r = 0.77, p = 0.016) after 8 weeks of therapy.
In patients with atopic asthma, changes in bronchial eosinophils and lung function during steroid therapy are closely related but do not occur simultaneously.
Keywords
Airway inflammation, Asthma, Biopsy, Eosinophil, Immunopathology
Pubmed
Web of science
Create date
24/07/2018 10:29
Last modification date
20/08/2019 15:26
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