The pathogenic role of tissue-resident immune cells in psoriasis.
Details
Serval ID
serval:BIB_6D1DC4431814
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The pathogenic role of tissue-resident immune cells in psoriasis.
Journal
Trends in Immunology
ISSN
1471-4906 (Print)
ISSN-L
1471-4906
Publication state
Published
Issued date
2007
Peer-reviewed
Oui
Volume
28
Number
2
Pages
51-57
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
Psoriasis is a common chronic inflammatory skin disease, the study of which might also be of considerable value to the understanding of other inflammatory and autoimmune-type diseases, such as rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis and diabetes mellitus. There is clear evidence that T cells and dendritic cells have a central role in psoriasis. Based on recent data from humans and animal models, we propose that a psoriasis lesion can be triggered and sustained by the local network of skin-resident immune cells. This concept focuses attention on local, rather than systemic, components of the immune system for rationalized therapeutic approaches of psoriasis and possibly also other chronic inflammatory diseases.
Keywords
Animals, Chronic Disease, Humans, Inflammation/genetics, Inflammation/immunology, Psoriasis/genetics, Psoriasis/immunology
Pubmed
Web of science
Create date
31/03/2009 11:43
Last modification date
20/08/2019 15:26