Is disease activity prior to fingolimod initiation predictive of response? Fingolimod as a "common" first line treatment.

Details

Serval ID
serval:BIB_6D1705A76DD6
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Is disease activity prior to fingolimod initiation predictive of response? Fingolimod as a "common" first line treatment.
Journal
Revue neurologique
Author(s)
Pantazou V., Du Pasquier R., Pot C., Le Goff G., Théaudin M.
ISSN
0035-3787 (Print)
ISSN-L
0035-3787
Publication state
In Press
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
In countries where fingolimod is available as first-line therapy without restrictions, we have an opportunity to observe long-term efficacy profile of this drug in treatment-naive patients according to their initial disease activity.
We retrospectively analysed the data of RRMS patients treated with FTY, focusing on 2 groups: 17 highly active patients (HA) defined as follows: ≥2 relapses in the year before treatment initiation and either≥1 Gd-enhancing T1 lesion or a significant increase in T2 lesion load from a baseline MRI; and 37 "not highly active" (NHA). We reviewed treatment efficacy (defined as NEDA-3), reasons for discontinuation and treatment tolerance in both groups.
Mean follow-up duration was 48.2 months, SD 18.4. Fingolimod efficiently reduced relapses (NHA 90.3% reduction, P<0.001, HA 84.9%, P<0.001), and new Gd enhancing lesions (NHA 85.4% reduction, P=0.019, HA 92.3%, P=0.043). The proportion of patients reaching NEDA-3 status was higher in the NHA group (NHA: 80% at 2 years and 66% at 4 years, HA: 58% at 2 years and 38% at 4 years, P=0.042). Fingolimod was discontinued in 20 cases, mainly because of lack of efficacy (n=15).
FTY is efficient in reducing relapses and new Gd enhancing lesions in both HA and NHA patients although the probability of achieving NEDA-3 over time is higher in early-treated treatment-naive NHA patients.
Keywords
Disease Modifying Treatment, Fingolimod, First Line Treatment, Highly Active, Multiple Sclerosis, Treatment Naive
Pubmed
Open Access
Yes
Create date
09/03/2021 14:37
Last modification date
12/03/2021 7:26
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