Cutaneous presentation of enteropathy-associated T-cell lymphoma masquerading as a DUSP22-rearranged CD30+ lymphoproliferation.

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State: Public
Version: Final published version
License: All rights reserved
Serval ID
serval:BIB_6CF9902CA42C
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Cutaneous presentation of enteropathy-associated T-cell lymphoma masquerading as a DUSP22-rearranged CD30+ lymphoproliferation.
Journal
Virchows Archiv
Author(s)
Bisig B., Cairoli A., Gaide O., Somja J., Bregnard C., Gaulard P., Xerri L., Lefort K., Missiaglia E., Gilliet M., Hohl D., Guenova E., de Leval L.
ISSN
1432-2307 (Electronic)
ISSN-L
0945-6317
Publication state
Published
Issued date
10/2022
Peer-reviewed
Oui
Volume
481
Number
4
Pages
653-657
Language
english
Notes
Publication types: Case Reports ; Editorial
Publication Status: ppublish
Abstract
DUSP22 gene rearrangements are recurrent in systemic and cutaneous ALK-negative anaplastic large cell lymphomas, rarely encountered in other cutaneous CD30+ lymphoproliferations, and typically absent in other peripheral T-cell lymphomas. We report the case of a 51-year-old woman, with longstanding celiac disease and a rapidly enlarging leg ulcer, due to a DUSP22-rearranged CD30+ T-cell lymphoproliferation. Subsequent history revealed an intestinal enteropathy-associated T-cell lymphoma (EATL). Identical monoclonal TR gene rearrangements and mutations in STAT3 and JAK1 typical of EATL were present in the cutaneous and intestinal lesions. No DUSP22 rearrangement was detected in the patient's intestinal tumour, nor in 15 additional EATLs tested. These findings indicate that DUSP22 rearrangements are not entirely specific of ALCLs, may rarely occur as a secondary aberration in EATL, and expand the differential diagnosis of DUSP22-rearranged cutaneous CD30+ lymphoproliferative disorders.
Keywords
Dual-Specificity Phosphatases/genetics, Enteropathy-Associated T-Cell Lymphoma/diagnosis, Enteropathy-Associated T-Cell Lymphoma/genetics, Female, Humans, Ki-1 Antigen, Lymphoma, Large-Cell, Anaplastic/diagnosis, Lymphoma, Large-Cell, Anaplastic/genetics, Lymphoma, Large-Cell, Anaplastic/pathology, Lymphoma, T-Cell, Peripheral, Middle Aged, Mitogen-Activated Protein Kinase Phosphatases/genetics, Receptor Protein-Tyrosine Kinases/genetics, Skin Neoplasms/diagnosis, Skin Neoplasms/genetics, CD30-positive lymphoproliferative disorder, Celiac disease, Cutaneous, DUSP22, Enteropathy-associated T-cell lymphoma, Skin ulcer
Pubmed
Web of science
Create date
04/04/2022 6:48
Last modification date
29/10/2022 5:40
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