A neural substrate for negative affect dictates female parental behavior.

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Version: Final published version
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Serval ID
serval:BIB_6CF94AE2FB4F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A neural substrate for negative affect dictates female parental behavior.
Journal
Neuron
Author(s)
Lecca S., Congiu M., Royon L., Restivo L., Girard B., Mazaré N., Bellone C., Telley L., Mameli M.
ISSN
1097-4199 (Electronic)
ISSN-L
0896-6273
Publication state
Published
Issued date
05/04/2023
Peer-reviewed
Oui
Volume
111
Number
7
Pages
1094-1103.e8
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Parental behaviors secure the well-being of newborns and concomitantly limit negative affective states in adults, which emerge when coping with neonatal distress becomes challenging. Whether negative-affect-related neuronal circuits orchestrate parental actions is unknown. Here, we identify parental signatures in lateral habenula neurons receiving bed nucleus of stria terminalis innervation ( <sup>BNST</sup> LHb). We find that LHb neurons of virgin female mice increase their activity following pup distress vocalization and are necessary for pup-call-driven aversive behaviors. LHb activity rises during pup retrieval, a behavior worsened by LHb inactivation. Intersectional cell identification and transcriptional profiling associate <sup>BNST</sup> LHb cells to parenting and outline a gene expression in female virgins similar to that in mothers but different from that in non-parental virgin male mice. Finally, tracking and manipulating <sup>BNST</sup> LHb cell activity demonstrates their specificity for encoding negative affect and pup retrieval. Thus, a negative affect neural circuit processes newborn distress signals and may limit them by guiding female parenting.
Keywords
Mice, Animals, Male, Female, Neurons/physiology, Avoidance Learning, Affect, Habenula/physiology, bed nucleus of the stria terminalis, lateral habenula, negative affect, parental behavior, pup retrieval, virgin female mice
Pubmed
Create date
13/02/2023 18:12
Last modification date
18/07/2024 7:06
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