A neural substrate for negative affect dictates female parental behavior.
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Version: Final published version
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UNIL restricted access
State: Public
Version: Final published version
License: Not specified
Serval ID
serval:BIB_6CF94AE2FB4F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A neural substrate for negative affect dictates female parental behavior.
Journal
Neuron
ISSN
1097-4199 (Electronic)
ISSN-L
0896-6273
Publication state
Published
Issued date
05/04/2023
Peer-reviewed
Oui
Volume
111
Number
7
Pages
1094-1103.e8
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
Parental behaviors secure the well-being of newborns and concomitantly limit negative affective states in adults, which emerge when coping with neonatal distress becomes challenging. Whether negative-affect-related neuronal circuits orchestrate parental actions is unknown. Here, we identify parental signatures in lateral habenula neurons receiving bed nucleus of stria terminalis innervation ( <sup>BNST</sup> LHb). We find that LHb neurons of virgin female mice increase their activity following pup distress vocalization and are necessary for pup-call-driven aversive behaviors. LHb activity rises during pup retrieval, a behavior worsened by LHb inactivation. Intersectional cell identification and transcriptional profiling associate <sup>BNST</sup> LHb cells to parenting and outline a gene expression in female virgins similar to that in mothers but different from that in non-parental virgin male mice. Finally, tracking and manipulating <sup>BNST</sup> LHb cell activity demonstrates their specificity for encoding negative affect and pup retrieval. Thus, a negative affect neural circuit processes newborn distress signals and may limit them by guiding female parenting.
Keywords
Mice, Animals, Male, Female, Neurons/physiology, Avoidance Learning, Affect, Habenula/physiology, bed nucleus of the stria terminalis, lateral habenula, negative affect, parental behavior, pup retrieval, virgin female mice
Pubmed
Create date
13/02/2023 18:12
Last modification date
18/07/2024 7:06