Role of T-cell-mediated inflammation in psoriasis: pathogenesis and targeted therapy
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Download: BIB_6CEDFA839BA0.P001.pdf (865.69 [Ko])
State: Public
Version: author
State: Public
Version: author
Serval ID
serval:BIB_6CEDFA839BA0
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Role of T-cell-mediated inflammation in psoriasis: pathogenesis and targeted therapy
Journal
Psoriasis: Targets and Therapy
ISSN
2230-326X (Electronic)
Publication state
Published
Issued date
2013
Volume
3
Pages
1-10
Language
english
Notes
pdf type: review
Abstract
Psoriasis is one of the most common chronic, inflammatory, T-cell-mediated autoimmune diseases. Over the past decade, increased knowledge of disease pathogenesis has fundamentally changed psoriasis treatment, with the introduction of biologics, and this has led to a multitude of improved selective targets providing potential therapeutic options. Indeed, numerous pathogenesis-based treatments are currently in development, as psoriasis has also become increasingly relevant for proof-of-concept studies. The purpose of this review was to summarize current knowledge of psoriasis immunopathogenesis, focusing on the T-cell-mediated immune response and its initiation. The authors describe recent advances in psoriasis treatment and discuss pathogenesis-based therapies that are currently in development or which could be envisioned for the future. Although current biologics are well tolerated, several issues such as long-term efficacy, long-term safety, and high costs keep driving the search for new and better therapies. With further advances in understanding disease pathogenesis, more genomic data from psoriasis patients becoming available, and potentially the identification of autoantigens in psoriasis, current research should lead to the development of a growing arsenal of improved targeted treatments and to further breakthrough immunotherapies.
Keywords
autoimmunity, autoimmune disease, immune response, immunopathogenesis
DOI
Open Access
Yes
Create date
14/02/2014 16:49
Last modification date
20/08/2019 14:26