Safety and immunogenicity of a three-component blood-stage malaria vaccine in adults living in an endemic area of Papua New Guinea
Details
Serval ID
serval:BIB_6CE031246808
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Safety and immunogenicity of a three-component blood-stage malaria vaccine in adults living in an endemic area of Papua New Guinea
Journal
Vaccine
ISSN
0264-410X (Print)
Publication state
Published
Issued date
05/2000
Volume
18
Number
23
Pages
2504-11
Notes
Clinical Trial
Clinical Trial, Phase I
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: May 22
Clinical Trial, Phase I
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: May 22
Abstract
A Phase I safety and immunogenicity study with a three-component blood-stage malaria vaccine was conducted in adult male subjects living in an endemic area of Papua New Guinea. The preparations were recombinant proteins which corresponded to parts of the two merozoite surface proteins of Plasmodium falciparum (MSP1 and 2), and of the ring-infected erythrocyte surface antigen (RESA). The three proteins were emulsified with the adjuvant Montanide ISA720. Ten subjects were injected twice (four weeks apart) with the vaccine formulation and two with the adjuvant alone. Mild pain at the site of injection was reported by about half of the subjects but no systemic reaction related to the formulation occurred. There was a sharp rise in geometric mean stimulation index after the second dose compared to baseline for MSP1 and RESA, while the rise was small for MSP2. Geometric mean antibody titres increased for MSP1 during the study, whereas they hardly changed for MSP2 and RESA. The vaccine formulation was safe when used in an already immune population. The vaccine induced good cellular responses, especially for MSP1 and RESA. Boosting of humoral responses was weak, probably because of high baseline antibody levels.
Keywords
Adjuvants, Immunologic
Adult
Animals
Antibodies, Protozoan/*biosynthesis/immunology
Antigens, Protozoan/*immunology
Cytokines/blood
Cytotoxicity, Immunologic
Humans
Immunization, Secondary
Malaria Vaccines/adverse effects/*immunology
Malaria, Falciparum/prevention & control
Male
Mannitol/analogs & derivatives/immunology
Merozoite Surface Protein 1/*immunology
Middle Aged
Oleic Acids/immunology
Papua New Guinea
Plasmodium falciparum/growth & development/*immunology
Protozoan Proteins/*immunology
Safety
T-Lymphocytes/immunology
*Vaccination/adverse effects
Pubmed
Web of science
Create date
28/01/2008 12:49
Last modification date
20/08/2019 15:26