The effects of arterial flow on platelet activation, thrombus growth, and stabilization.

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Serval ID
serval:BIB_6CDFBD073681
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The effects of arterial flow on platelet activation, thrombus growth, and stabilization.
Journal
Cardiovascular Research
Author(s)
Cosemans J.M., Angelillo-Scherrer A., Mattheij N.J., Heemskerk J.W.
ISSN
1755-3245 (Electronic)
ISSN-L
0008-6363
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
99
Number
2
Pages
342-352
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish
Abstract
Injury of an arterial vessel wall acutely triggers a multifaceted process of thrombus formation, which is dictated by the high-shear flow conditions in the artery. In this overview, we describe how the classical concept of arterial thrombus formation and vascular occlusion, driven by platelet activation and fibrin formation, can be extended and fine-tuned. This has become possible because of recent insight into the mechanisms of: (i) platelet-vessel wall and platelet-platelet communication, (ii) autocrine platelet activation, and (iii) platelet-coagulation interactions, in relation to blood flow dynamics. We list over 40 studies with genetically modified mice showing a role of platelet and plasma proteins in the control of thrombus stability after vascular injury. These include multiple platelet adhesive receptors and other junctional molecules, components of the ADP receptor signalling cascade to integrin activation, proteins controlling platelet shape, and autocrine activation processes, as well as multiple plasma proteins binding to platelets and proteins of the intrinsic coagulation cascade. Regulatory roles herein of the endothelium and other blood cells are recapitulated as well. Patient studies support the contribution of platelet- and coagulation activation in the regulation of thrombus stability. Analysis of the factors determining flow-dependent thrombus stabilization and embolus formation in mice will help to understand the regulation of this process in human arterial disease.
Pubmed
Web of science
Open Access
Yes
Create date
11/08/2013 9:27
Last modification date
25/09/2019 7:09
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