Severe radiation-induced liver disease following localized radiation therapy for biliopancreatic carcinoma: activation of hepatic stellate cells as an early event.

Details

Serval ID
serval:BIB_6CDA9D96231E
Type
Article: article from journal or magazin.
Collection
Publications
Title
Severe radiation-induced liver disease following localized radiation therapy for biliopancreatic carcinoma: activation of hepatic stellate cells as an early event.
Journal
Hepatology (baltimore, Md.)
Author(s)
Sempoux C., Horsmans Y., Geubel A., Fraikin J., Van Beers B.E., Gigot J.F., Lerut J., Rahier J.
ISSN
0270-9139 (Print)
ISSN-L
0270-9139
Publication state
Published
Issued date
1997
Peer-reviewed
Oui
Volume
26
Number
1
Pages
128-134
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
Radiation-induced liver disease is recorded as a form of veno-occlusive disease. Its pathogenesis remains unclear even if the initial injury likely occurs in the endothelial cells of central veins. The aim of our study was to investigate liver morphological features in relation to alpha-isoform of smooth muscle actin expression in hepatic stellate cells in six patients treated by localized radiotherapy on the biliopancreatic area. Within the month after completion of treatment, an activation of hepatic stellate cells strictly confined to irradiated areas and coinciding with congestive changes was observed. At a later stage, collagen deposition gradually increased, replacing the congestive and destroyed areas. This new fibrotic tissue also contained numerous alpha-smooth muscle positive cells. Our data suggest that early hepatic stellate cells activation coinciding with congestive changes plays an important role in radiation liver injury and ensuing fibrosis.
Keywords
Actins/metabolism, Adult, Aged, Bile Duct Neoplasms/complications, Bile Duct Neoplasms/radiotherapy, Biopsy, Female, Humans, Liver/metabolism, Liver/pathology, Liver Diseases/etiology, Liver Diseases/metabolism, Male, Middle Aged, Pancreatic Neoplasms/complications, Pancreatic Neoplasms/radiotherapy, Radiation Injuries/etiology, Radiation Injuries/pathology, Radiotherapy/adverse effects
Pubmed
Web of science
Create date
20/10/2016 17:39
Last modification date
20/08/2019 15:26
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