Virus-like particles induce robust human T-helper cell responses.

Details

Serval ID
serval:BIB_6CC8896DD5F6
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Virus-like particles induce robust human T-helper cell responses.
Journal
European Journal of Immunology
Author(s)
Braun M., Jandus C., Maurer P., Hammann-Haenni A., Schwarz K., Bachmann M.F., Speiser D.E., Romero P.
ISSN
1521-4141 (Electronic)
ISSN-L
0014-2980
Publication state
Published
Issued date
2012
Volume
42
Number
2
Pages
330-340
Language
english
Notes
Publication types: Journal Article
Abstract
Among synthetic vaccines, virus-like particles (VLPs) are used for their ability to induce strong humoral responses. Very little is reported on VLP-based-vaccine-induced CD4(+) T-cell responses, despite the requirement of helper T cells for antibody isotype switching. Further knowledge on helper T cells is also needed for optimization of CD8(+) T-cell vaccination. Here, we analysed human CD4(+) T-cell responses to vaccination with MelQbG10, which is a Qβ-VLP covalently linked to a long peptide derived from the melanoma self-antigen Melan-A. In all analysed patients, we found strong antibody responses of mainly IgG1 and IgG3 isotypes, and concomitant Th1-biased CD4(+) T-cell responses specific for Qβ. Although less strong, comparable B- and CD4(+) T-cell responses were also found specific for the Melan-A cargo peptide. Further optimization is required to shift the response more towards the cargo peptide. Nevertheless, the data demonstrate the high potential of VLPs for inducing humoral and cellular immune responses by mounting powerful CD4(+) T-cell help.
Pubmed
Web of science
Open Access
Yes
Create date
16/02/2012 15:58
Last modification date
20/08/2019 15:26
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