A comparison of frailty of primary neurons, embryonic, and aging mouse cortical layers.

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State: Public
Version: author
Serval ID
serval:BIB_6CC83F211FB2
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A comparison of frailty of primary neurons, embryonic, and aging mouse cortical layers.
Journal
Neurobiology of Aging
Author(s)
Fugistier P., Vallet P.G., Leuba G., Piotton F., Marin P., Bouras C., Savioz A.
ISSN
1558-1497 (Electronic)
ISSN-L
0197-4580
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
35
Number
2
Pages
322-330
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
Superficial layers I to III of the human cerebral cortex are more vulnerable toward Aβ peptides than deep layers V to VI in aging. Three models of layers were used to investigate this pattern of frailty. First, primary neurons from E14 and E17 embryonic murine cortices, corresponding respectively to future deep and superficial layers, were treated either with Aβ1-42, okadaic acid, or kainic acid. Second, whole E14 and E17 embryonic cortices, and third, in vitro separated deep and superficial layers of young and old C57BL/6J mice, were treated identically. We observed that E14 and E17 neurons in culture were prone to death after the Aβ and particularly the kainic acid treatment. This was also the case for the superficial layers of the aged cortex, but not for the embryonic, the young cortex, and the deep layers of the aged cortex. Thus, the aged superficial layers appeared to be preferentially vulnerable against Aβ and kainic acid. This pattern of vulnerability corresponds to enhanced accumulation of senile plaques in the superficial cortical layers with aging and Alzheimer's disease.
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Web of science
Create date
14/11/2013 16:47
Last modification date
20/08/2019 14:26
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