Stress undermines reward-guided cognitive performance through synaptic depression in the lateral habenula.

Details

Serval ID
serval:BIB_6CC094B1D075
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Stress undermines reward-guided cognitive performance through synaptic depression in the lateral habenula.
Journal
Neuron
Author(s)
Nuno-Perez A., Trusel M., Lalive A.L., Congiu M., Gastaldo D., Tchenio A., Lecca S., Soiza-Reilly M., Bagni C., Mameli M.
ISSN
1097-4199 (Electronic)
ISSN-L
0896-6273
Publication state
Published
Issued date
17/03/2021
Peer-reviewed
Oui
Volume
109
Number
6
Pages
947-956.e5
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Weighing alternatives during reward pursuit is a vital cognitive computation that, when disrupted by stress, yields aspects of neuropsychiatric disorders. To examine the neural mechanisms underlying these phenomena, we employed a behavioral task in which mice were confronted by a reward and its omission (i.e., error). The experience of error outcomes engaged neuronal dynamics within the lateral habenula (LHb), a subcortical structure that supports appetitive behaviors and is susceptible to stress. A high incidence of errors predicted low strength of habenular excitatory synapses. Accordingly, stressful experiences increased error choices while decreasing glutamatergic neurotransmission onto LHb neurons. This synaptic adaptation required a reduction in postsynaptic AMPA receptors (AMPARs), irrespective of the anatomical source of glutamate. Bidirectional control of habenular AMPAR transmission recapitulated and averted stress-driven cognitive deficits. Thus, a subcortical synaptic mechanism vulnerable to stress underlies behavioral efficiency during cognitive performance.
Keywords
Animals, Cognition/physiology, Habenula/physiology, Male, Mice, Mice, Inbred C57BL, Neuronal Plasticity/physiology, Receptors, AMPA/metabolism, Reward, Stress, Psychological/physiopathology, Synaptic Transmission/physiology, AMPA receptors, lateral habenula, reward-guided behaviors, stress
Pubmed
Open Access
Yes
Create date
08/02/2021 11:51
Last modification date
04/10/2022 5:38
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