Neurotoxicant-induced inflammatory response in three-dimensional brain cell cultures.
Details
Serval ID
serval:BIB_6CBE69625C7B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Neurotoxicant-induced inflammatory response in three-dimensional brain cell cultures.
Journal
Human and Experimental Toxicology
ISSN
0960-3271 (Print)
ISSN-L
0960-3271
Publication state
Published
Issued date
04/2007
Volume
26
Number
4
Pages
339-346
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
Brain inflammatory response is triggered by the activation of microglial cells and astrocytes in response to various types of CNS injury, including neurotoxic insults. Its outcome is determined by cellular interactions, inflammatory mediators, as well as trophic and/or cytotoxic signals, and depends on many additional factors such as the intensity and duration of the insult, the extent of both the primary neuronal damage and glial reactivity and the developmental stage of the brain. Depending on particular circumstances, the brain inflammatory response can promote neuroprotection, regeneration or neurodegeneration. Glial reactivity, regarded as the central phenomenon of brain inflammation, has also been used as an early marker of neurotoxicity. To study the mechanisms underlying the glial reactivity, serum-free aggregating brain cell cultures were used as an in vitro model to test the effects of conventional neurotoxicants such as organophosphate pesticides, heavy metals, excitotoxins and mycotoxins. This approach was found to be relevant and justified by the complex cell-cell interactions involved in the brain inflammatory response, the variability of the glial reactions and the multitude of mediators involved. All these variables need to be considered for the elucidation of the specific cellular and molecular reactions and their consequences caused by a given chemical insult.
Keywords
Brain/growth & development, Brain/pathology, Cells, Cultured, Cytological Techniques, Glial Fibrillary Acidic Protein/metabolism, Humans, Inflammation/chemically induced, Inflammation/pathology, Neuroglia/pathology, Neurons/pathology, Neurotoxicity Syndromes/pathology
Pubmed
Web of science
Create date
24/01/2008 14:11
Last modification date
20/08/2019 15:26