Pulmonary stress injury within physiological ranges of airway and vascular pressures.

Details

Serval ID
serval:BIB_6CBDFACD9969
Type
Article: article from journal or magazin.
Collection
Publications
Title
Pulmonary stress injury within physiological ranges of airway and vascular pressures.
Journal
Journal of critical care
Author(s)
Guery B.P., DeBoisblanc B.P., Fialdes P., Sarphy T.G., Nelson S., Chidiac C., Beaucaire G., Summer W.R., Mason C.M.
ISSN
0883-9441 (Print)
ISSN-L
0883-9441
Publication state
Published
Issued date
06/1998
Peer-reviewed
Oui
Volume
13
Number
2
Pages
58-66
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
The aim of this study was to assess the respective role of a small elevation in pulmonary capillary pressure, airway pressure, or both on alveolar capillary barrier permeability in an isolated perfused rat lung model.
Four groups were studied with low or high airway pressure (LA: 10 mL/kg (tidal volume); HA: 20 mL/kg), low or high pulmonary artery pressure (LP: 9 mm Hg; HP: 12 mm Hg): LALP, HALP, LAHP, and HAHP. The lungs were ventilated and perfused ex vivo for 30 minutes. Quantification of fluorescein isothiocyanate-labeled (FITC) dextran in bronchoalveolar lavage (BAL) fluid and radiolabeled tracers assessed alveolar capillary barrier permeability.
BALF FITC-dextran was similar in the three groups with either one or two low-pressure parameters (LALP, LAHP, HALP), but high amounts were found in the HAHP group (375.2 x 10(-6) mg/mL v, respectively, 21.4, 26.2, and 30 x 10(-6) mg/mL, P = .0001). These results were consistent with the albumin space and extravascular lung water: higher values only in the HAHP group statistically different from the other groups (P < .002). Interalveolar pore examined with scanning electron microscopy showed an increase in diameters between LALP and HAHP (P < .0001).
We can conclude that elevation of either the pulmonary artery pressure from 8 to 11 mm Hg or the alveolar pressure from 10 to 15 mm Hg alone does not change the permeability of the alveolar capillary membrane; however, there is an additive effect of these pressures.
Keywords
Air Pressure, Animals, Barotrauma/pathology, Barotrauma/physiopathology, Blood-Air Barrier/physiology, Capillary Permeability/physiology, Extravascular Lung Water/physiology, Lung/pathology, Lung/physiopathology, Lung Injury, Microcirculation/pathology, Microcirculation/physiopathology, Microscopy, Electron, Scanning, Perfusion, Positive-Pressure Respiration, Pulmonary Alveoli/blood supply, Pulmonary Alveoli/pathology, Pulmonary Wedge Pressure/physiology, Rats, Respiratory Distress Syndrome/blood, Respiratory Distress Syndrome/physiopathology, Tidal Volume/physiology
Pubmed
Web of science
Create date
29/04/2021 10:59
Last modification date
17/07/2023 15:11
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