Amnestic Syndrome in Memory Clinics: Similar Morphological Brain Patterns in Older Adults with and without Alzheimer's Disease.
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UNIL restricted access
State: Public
Version: Author's accepted manuscript
License: Not specified
Serval ID
serval:BIB_6CAF0918D523
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Amnestic Syndrome in Memory Clinics: Similar Morphological Brain Patterns in Older Adults with and without Alzheimer's Disease.
Journal
Journal of Alzheimer's disease
ISSN
1875-8908 (Electronic)
ISSN-L
1387-2877
Publication state
Published
Issued date
2024
Peer-reviewed
Oui
Volume
100
Number
1
Pages
333-343
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
Amnestic syndrome of the hippocampal type (ASHT) in Memory Clinics is a presentation common to Alzheimer's disease (AD). However, ASHT can be found in other neurodegenerative disorders.
To compare brain morphometry including hippocampal volumes between amnestic older adults with and without AD pathology and investigate their relationship with memory performance and cerebrospinal fluid (CSF) biomarkers.
Brain morphometry of 92 consecutive patients (72.5±6.8 years old; 39% female) with Free and Cued Selective Recall Reminding Test (FCSRT) total recall < 40/48 was assessed with an automated algorithm and compared between AD and non-AD patients, as defined by CSF biomarkers.
AD and non-AD patients presented comparable brain morphology. Total recall was associated to hippocampal volume irrespectively from AD pathology.
Brain morphometry, including hippocampal volumes, is similar between AD and non-AD older adults with ASHT evaluated in a Memory Clinic, underlying the importance of using molecular biomarkers for the diagnosis of AD.
To compare brain morphometry including hippocampal volumes between amnestic older adults with and without AD pathology and investigate their relationship with memory performance and cerebrospinal fluid (CSF) biomarkers.
Brain morphometry of 92 consecutive patients (72.5±6.8 years old; 39% female) with Free and Cued Selective Recall Reminding Test (FCSRT) total recall < 40/48 was assessed with an automated algorithm and compared between AD and non-AD patients, as defined by CSF biomarkers.
AD and non-AD patients presented comparable brain morphology. Total recall was associated to hippocampal volume irrespectively from AD pathology.
Brain morphometry, including hippocampal volumes, is similar between AD and non-AD older adults with ASHT evaluated in a Memory Clinic, underlying the importance of using molecular biomarkers for the diagnosis of AD.
Keywords
Humans, Female, Aged, Male, Alzheimer Disease/pathology, Amnesia/pathology, Amnesia/diagnostic imaging, Magnetic Resonance Imaging, Hippocampus/pathology, Hippocampus/diagnostic imaging, Brain/pathology, Brain/diagnostic imaging, Biomarkers/cerebrospinal fluid, Neuropsychological Tests, Aged, 80 and over, Mental Recall/physiology, Amyloid beta-Peptides/cerebrospinal fluid, Organ Size, Alzheimer’s disease, amnestic, hippocampus, magnetic resonance imaging
Pubmed
Web of science
Create date
20/06/2024 16:19
Last modification date
04/10/2024 7:04