Long-term outcome after cognitive and behavioral regression in non-lesional epilepsy with CSWS

Details

Serval ID
serval:BIB_6C81C5361375
Type
Inproceedings: an article in a conference proceedings.
Publication sub-type
Abstract (Abstract): shot summary in a article that contain essentials elements presented during a scientific conference, lecture or from a poster.
Collection
Publications
Institution
Title
Long-term outcome after cognitive and behavioral regression in non-lesional epilepsy with CSWS
Title of the conference
10th European Congress on Epileptology
Author(s)
Perez E. Roulet , Deonna T., Mayor-Dubois C., Valenti-Hirsch M. P., Hirsch E., Metz-Lutz M., De Saint-Martin A., Seegmueller C.
Address
Sep 30-OCT 04, 2012; London, England
ISBN
0013-9580
ISSN-L
0013-9580
Publication state
Published
Issued date
2012
Volume
53
Series
Epilepsia
Pages
76
Language
english
Abstract
Purpose: To present the long-term outcome (LTO) of 10 adolescents and young adults with documented cognitive and behavioral regression as children due to non-lesional focal, mainly frontal epilepsy with continuous spike-waves during slow wave sleep (CSWS).
Method: Past medical and EEG data of all patients were reviewed and neuropsychological tests exploring main cognitive functions were administered.
Result: After a mean duration of follow-up of 15.6 years (range 8-23 years), none of the 10 patients had recovered fully, but four regained borderline to normal intelligence and were almost independent. Patients with prolonged global intellectual regression had the worst outcome, whereas those with more specific and short-lived deficits recovered best. The marked behavioral disorders that were so disturbing during the active period (AP) resolved in all but one patient. Executive functions were neither severely nor homogenously affected. Three patients with a frontal syndrome during the AP disclosed only mild residual executive and social cognition deficits. The main cognitive gains occurred shortly after the AP, but qualitative improvements continued to occur. LTO correlated best with duration of CSWS.
Conclusion: Our findings emphasize that cognitive recovery after cessation of CSWS depends on the severity and duration of the initial regression. None of our patients had major executive and social cognition deficits with preserved intelligence as reported in adults with destructive lesions of the frontal lobes during childhood. Early recognition of epilepsy with CSWS and rapid introduction of effective therapy are crucial for a best possible outcome.
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Create date
18/12/2012 15:52
Last modification date
20/08/2019 15:26
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