CSF biomarkers for the differential diagnosis of Alzheimer's disease: A large-scale international multicenter study.

Details

Serval ID
serval:BIB_6C1EDDC275C6
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
CSF biomarkers for the differential diagnosis of Alzheimer's disease: A large-scale international multicenter study.
Journal
Alzheimer's and Dementia
Author(s)
Ewers M., Mattsson N., Minthon L., Molinuevo J.L., Antonell A., Popp J., Jessen F., Herukka S.K., Soininen H., Maetzler W., Leyhe T., Bürger K., Taniguchi M., Urakami K., Lista S., Dubois B., Blennow K., Hampel H.
ISSN
1552-5279 (Electronic)
ISSN-L
1552-5260
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
11
Number
11
Pages
1306-1315
Language
english
Abstract
INTRODUCTION: The aim of this study was to test the diagnostic value of cerebrospinal fluid (CSF) beta-amyloid (Aβ1-42), phosphorylated tau, and total tau (tau) to discriminate Alzheimer's disease (AD) dementia from other forms of dementia.
METHODS: A total of 675 CSF samples collected at eight memory clinics were obtained from healthy controls, AD dementia, subjective memory impairment, mild cognitive impairment, vascular dementia, Lewy body dementia (LBD), fronto-temporal dementia (FTD), depression, or other neurological diseases.
RESULTS: CSF Aβ1-42 showed the best diagnostic accuracy among the CSF biomarkers. At a sensitivity of 85%, the specificity to differentiate AD dementia against other diagnoses ranged from 42% (for LBD, 95% confidence interval or CI = 32-62) to 77% (for FTD, 95% CI = 62-90).
DISCUSSION: CSF Aβ1-42 discriminates AD dementia from FTD, but shows significant overlap with other non-AD forms of dementia, possibly reflecting the underlying mixed pathologies.
Keywords
Aged, Aged, 80 and over, Alzheimer Disease/cerebrospinal fluid, Alzheimer Disease/diagnosis, Amyloid beta-Peptides/cerebrospinal fluid, Biomarkers/cerebrospinal fluid, Diagnosis, Differential, Female, Humans, Internationality, Male, Middle Aged, Peptide Fragments/cerebrospinal fluid, Phosphorylation, Sensitivity and Specificity, Spinal Puncture, tau Proteins/cerebrospinal fluid
Pubmed
Web of science
Create date
08/02/2016 11:13
Last modification date
20/08/2019 15:26
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