Aggravation of experimental cutaneous leishmaniasis in mice by administration of interleukin 3

Details

Serval ID
serval:BIB_6C1CD27E12E7
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Aggravation of experimental cutaneous leishmaniasis in mice by administration of interleukin 3
Journal
European Journal of Immunology
Author(s)
Feng  Z. Y., Louis  J., Kindler  V., Pedrazzini  T., Eliason  J. F., Behin  R., Vassalli  P.
ISSN
0014-2980 (Print)
Publication state
Published
Issued date
08/1988
Volume
18
Number
8
Pages
1245-51
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Aug
Abstract
Previous studies from our laboratory have shown that some in vitro maintained Leishmania major-specific L3T4+ T cells were capable of exacerbating cutaneous leishmaniasis after adoptive transfer to normal syngeneic mice. Results presented in this report show that these cells released substantial amounts of interleukin 3 (IL 3) and granulocyte-macrophage colony-stimulating factors after specific stimulation in vitro. In order to assess the involvement of such lymphokines in the exacerbation of cutaneous leishmaniasis by these L3T4+ T cells, the effect of the administration of important doses of IL 3 on the course of infection with L. major was investigated. The treatment of genetically susceptible BALB/c mice with IL 3 resulted in an enhancement of the size of lesions and favored the multiplication of parasites at anatomical sites distant from the primary lesion. Although IL 3 did not modify the development of lesions in genetically resistant CBA mice, this lymphokine promoted the growth of Leishmania in lymph node draining the lesion. Finally, the addition of IL 3 to macrophages parasitized in vitro enhanced the survival of intracellular Leishmania major.
Keywords
Animals Antigens, Differentiation, T-Lymphocyte/analysis Colony-Stimulating Factors/*physiology Granulocyte-Macrophage Colony-Stimulating Factor Growth Substances/*physiology Interleukin-3/pharmacology/*physiology Leishmania tropica/growth & development Leishmaniasis/*immunology/pathology Lymphocyte Activation Lymphocyte Culture Test, Mixed Macrophages/parasitology Mice Mice, Inbred Strains T-Lymphocytes/*immunology
Pubmed
Web of science
Create date
25/01/2008 8:45
Last modification date
20/08/2019 14:26
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