Genonets server-a web server for the construction, analysis and visualization of genotype networks.

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Version: Final published version
Serval ID
serval:BIB_6C199A2E818E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Genonets server-a web server for the construction, analysis and visualization of genotype networks.
Journal
Nucleic Acids Research
Author(s)
Khalid F., Aguilar-Rodríguez J., Wagner A., Payne J.L.
ISSN
1362-4962 (Electronic)
ISSN-L
0305-1048
Publication state
Published
Issued date
2016
Peer-reviewed
Oui
Volume
44
Number
W1
Pages
W70-W76
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
A genotype network is a graph in which vertices represent genotypes that have the same phenotype. Edges connect vertices if their corresponding genotypes differ in a single small mutation. Genotype networks are used to study the organization of genotype spaces. They have shed light on the relationship between robustness and evolvability in biological systems as different as RNA macromolecules and transcriptional regulatory circuits. Despite the importance of genotype networks, no tool exists for their automatic construction, analysis and visualization. Here we fill this gap by presenting the Genonets Server, a tool that provides the following features: (i) the construction of genotype networks for categorical and univariate phenotypes from DNA, RNA, amino acid or binary sequences; (ii) analyses of genotype network topology and how it relates to robustness and evolvability, as well as analyses of genotype network topography and how it relates to the navigability of a genotype network via mutation and natural selection; (iii) multiple interactive visualizations that facilitate exploratory research and education. The Genonets Server is freely available at http://ieu-genonets.uzh.ch.
Pubmed
Web of science
Open Access
Yes
Create date
10/05/2016 17:44
Last modification date
20/08/2019 14:26
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