Expression pattern of mouse mammary tumor virus in transgenic mice carrying exogenous proviruses of different origins.

Details

Serval ID
serval:BIB_6C092698B4A4
Type
Article: article from journal or magazin.
Collection
Publications
Title
Expression pattern of mouse mammary tumor virus in transgenic mice carrying exogenous proviruses of different origins.
Journal
Journal of Virology
Author(s)
Rollini P., Billotte J., Kolb E., Diggelmann H.
ISSN
0022-538X (Print)
ISSN-L
0022-538X
Publication state
Published
Issued date
1992
Volume
66
Number
7
Pages
4580-4586
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
To study the tissue specificity of mouse mammary tumor virus (MMTV) gene expression, we developed two series of transgenic mice, containing the MMTV proviral DNA of mammary (GR) and kidney (C3H-K) origin. The expression pattern in the MMTV(GR) transgenic mice is very similar to that observed in infected animals, e.g., a strong preference for viral expression in the lactating mammary glands and lower levels of expression in salivary glands, lymphoid tissues, and male reproductive organs. One line of transgenic mice carrying the C3H-K provirus has a similar expression pattern, indicating that MMTV(C3H-K), despite a striking alteration in the U3 region of its long terminal repeat, can be expressed in the same tissues as the wild-type MMTV.
Keywords
Animals, Female, Gene Expression Regulation, Viral, Male, Mammary Tumor Virus, Mouse/genetics, Mammary Tumor Virus, Mouse/metabolism, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Transgenic, Nucleic Acid Hybridization, Organ Specificity, Proviruses/genetics
Pubmed
Web of science
Create date
11/11/2011 12:13
Last modification date
20/08/2019 15:26
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