Control of eukaryotic phosphate homeostasis by inositol polyphosphate sensor domains.

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State: Public
Version: author
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Serval ID
serval:BIB_6BE61A0DBC36
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Control of eukaryotic phosphate homeostasis by inositol polyphosphate sensor domains.
Journal
Science
Author(s)
Wild R., Gerasimaite R., Jung J.Y., Truffault V., Pavlovic I., Schmidt A., Saiardi A., Jessen H.J., Poirier Y., Hothorn M., Mayer A.
ISSN
1095-9203 (Electronic)
ISSN-L
0036-8075
Publication state
Published
Issued date
2016
Peer-reviewed
Oui
Volume
352
Number
6288
Pages
986-990
Language
english
Abstract
Phosphorus is a macronutrient taken up by cells as inorganic phosphate (P(i)). How cells sense cellular P(i) levels is poorly characterized. Here, we report that SPX domains--which are found in eukaryotic phosphate transporters, signaling proteins, and inorganic polyphosphate polymerases--provide a basic binding surface for inositol polyphosphate signaling molecules (InsPs), the concentrations of which change in response to P(i) availability. Substitutions of critical binding surface residues impair InsP binding in vitro, inorganic polyphosphate synthesis in yeast, and P(i) transport in Arabidopsis In plants, InsPs trigger the association of SPX proteins with transcription factors to regulate P(i) starvation responses. We propose that InsPs communicate cytosolic P(i) levels to SPX domains and enable them to interact with a multitude of proteins to regulate P(i) uptake, transport, and storage in fungi, plants, and animals.
Pubmed
Web of science
Create date
27/04/2016 13:15
Last modification date
28/11/2020 6:21
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