Metabolic guidance and stress in tumors modulate antigen-presenting cells.

Details

Serval ID
serval:BIB_6BDDFB239E9D
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Metabolic guidance and stress in tumors modulate antigen-presenting cells.
Journal
Oncogenesis
Author(s)
Park J., Wang L., Ho P.C.
ISSN
2157-9024 (Print)
ISSN-L
2157-9024
Publication state
Published
Issued date
16/10/2022
Peer-reviewed
Oui
Volume
11
Number
1
Pages
62
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
Successful antitumor immunity largely relies on efficient T cell priming by antigen-presenting cells (APCs); however, the capacity of APCs is found to be defective in many cancers. Metabolically reprogrammed cancer cells support the energetic and biosynthetic demands of their high proliferation rates by exploiting nutrients available in the tumor microenvironment (TME), which in turn limits proper metabolic reprogramming of APCs during recruitment, differentiation, activation and antigen presentation. Furthermore, some metabolites generated by the TME are unfavorable to antitumor immunity. This review summarizes recent studies on the metabolic features of APCs and their functionality in the TME. Particularly, we will describe how APCs respond to altered TME and how metabolic byproducts from cancer and immunomodulatory cells affect APCs. Finally, we introduce the current status of APC-oriented research and clinical trials targeting metabolic features to boost efficient immunotherapy.
Pubmed
Web of science
Open Access
Yes
Create date
24/10/2022 11:42
Last modification date
02/11/2022 6:41
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