Colorectal Cancer, Pathology and Genetics

Details

Serval ID
serval:BIB_6BDA362D8FA2
Type
A part of a book
Publication sub-type
Chapter: chapter ou part
Collection
Publications
Institution
Title
Colorectal Cancer, Pathology and Genetics
Title of the book
Encyclopedia of Cancer
Author(s)
Bosman FT
Publisher
Elsevier
ISBN
9780128012383
Publication state
Published
Issued date
2018
Series
Reference Module in Biomedical Sciences
Pages
428-443
Edition
3rd ed.
Language
english
Abstract
Colorectal cancer is among the most frequent of human cancers with an estimated 1.4 million new cases of CRC occurred worldwide in 2012. Most colorectal cancers are sporadic, but about 20% of colorectal cancers arise in the context of a familial syndrome or as a complication of inflammatory bowel disease, and these cancers have distinct characteristics. Colorectal cancers develop in different molecular patterns, which are known as the chromosomal instability (CIN), microsatellite instability (MIN) and CpG island methylator phenotype (CIMP) pathways. Results of recent molecular profiling studies have clearly established molecular and genetic heterogeneity of colorectal cancer beyond these established categories, which has resulted in consensus molecular subtypes. About 40% of colorectal cancers are KRAS mutated and these will not respond to EGFR blocking therapies. Microsatellite instable colorectal cancers have gained significant interest recently as they epitomize a category of hypermutating immunogenic tumors, which respond well to immunotherapy through blocking of the PD1 immune-checkpoint.
Keywords
Adenocarcinoma, Adenoma-carcinoma sequence, Chromosomal instability, Colon, Consensus molecular subtype, CpG island methylator phenotype, Familial adenomatous polyposis, Lynch syndrome, MAP syndrome, Microsatellite instability, Peutz-Jeghers syndrome, Polymerase proofreading-associated polyposis, Rectum
Create date
23/11/2018 8:54
Last modification date
20/08/2019 14:26
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