Transfer of cryopreserved-thawed embryos: the natural cycle versus controlled preparation of the endometrium with gonadotropin-releasing hormone agonist and exogenous estradiol and progesterone (GEEP)

Details

Serval ID
serval:BIB_6BD3D4889E85
Type
Article: article from journal or magazin.
Collection
Publications
Title
Transfer of cryopreserved-thawed embryos: the natural cycle versus controlled preparation of the endometrium with gonadotropin-releasing hormone agonist and exogenous estradiol and progesterone (GEEP)
Journal
Fertility and Sterility
Author(s)
Schmidt  C. L., de Ziegler  D., Gagliardi  C. L., Mellon  R. W., Taney  F. H., Kuhar  M. J., Colon  J. M., Weiss  G.
ISSN
0015-0282
Publication state
Published
Issued date
10/1989
Peer-reviewed
Oui
Volume
52
Number
4
Pages
609-16
Notes
Journal Article --- Old month value: Oct
Abstract
Modeled on our successful experience with oocyte donation, we present a novel, viable approach to cryopreserved-thawed embryo transfers (ETs) in women with recalcitrant ovarian dysfunction: gonadotropin-releasing hormone agonist and exogenous estradiol and progesterone (GEEP). After attainment of ovarian suppression, seven such women received physiological steroidal replacement regimens with cryopreserved-thawed ETs prospectively synchronized with the 4th day of progesterone administration and two conceived. These GEEP cycles and cryopreserved-thawed ETs were prospectively compared with cryopreserved-thawed ETs performed on the 4th day of exposure to progesterone in 20 spontaneous cycles and in 5 oocyte donation-steroidal replacement cycles. Pregnancies occurred after three cryopreserved-thawed ETs in each of these groups. We conclude that GEEP constitutes a successful preparation for cryopreserved-thawed ETs, at the least, in women with ovulatory dysfunction.
Keywords
Adult *Cryopreservation *Embryo Transfer Endometrium/*drug effects Estradiol/blood/*therapeutic use Female Humans Infertility/therapy Luteinizing Hormone/blood/urine *Menstrual Cycle Pituitary Hormone-Releasing Hormones/*physiology Pregnancy/blood Progesterone/blood/*therapeutic use
Pubmed
Web of science
Create date
28/02/2008 12:37
Last modification date
20/08/2019 15:26
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