Serum 25-hydroxyvitamin D predicts severity and prognosis in stroke patients.

Details

Serval ID
serval:BIB_6BC70303B88A
Type
Article: article from journal or magazin.
Collection
Publications
Title
Serum 25-hydroxyvitamin D predicts severity and prognosis in stroke patients.
Journal
European journal of neurology
Author(s)
Daubail B., Jacquin A., Guilland J.C., Hervieu M., Osseby G.V., Rouaud O., Giroud M., Béjot Y.
ISSN
1468-1331 (Electronic)
ISSN-L
1351-5101
Publication state
Published
Issued date
01/2013
Peer-reviewed
Oui
Volume
20
Number
1
Pages
57-61
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
We aimed to evaluate the association between 25-hydroxyvitamin D (25(OH)D) levels and both clinical severity at admission and outcome at discharge in stroke patients.
From February 2010 to December 2010, consecutive stroke patients admitted to the Department of Neurology of Dijon, France, were identified. Clinical information was collected. Serum concentration of 25(OH)D was measured at baseline. Stroke severity was assessed at admission using the NIHSS score. Functional impairment was evaluated at discharge using the modified Rankin scale (m-Rankin). Multivariate analyses were performed using logistic regression models.
Of the 386 recorded patients, serum 25(OH)D levels were obtained in 382 (median value = 35.1 nM; IQR = 21-57.8). At admission, 208 patients had a NIHSS ≤5, with a higher mean 25(OH)D level than that observed in patients with moderate-to-high severity (45.9 vs. 38.6 nM, P < 0.001). In multivariate analyses, a 25(OH)D level in the lowest tertile (<25.7 nM) was a predictor of a NIHSS ≥6 (OR = 1.67; 95% CI = 1.05-2.68; P = 0.03). The mean 25(OH)D level was lower in patients with moderate-to-severe handicap at discharge (m-Rankin 3-6) than in patients with no or mild handicap (35.0 vs. 47.5 nM, P < 0.001). In multivariate analyses, the lowest tertile of 25(OH)D level (<25.7 nM) was associated with a higher risk of moderate-to-severe handicap (OR = 2.06; 95% CI = 1.06-3.94; P = 0.03).
A low serum 25(OH)D level is a predictor of both severity at admission and poor early functional outcome in stroke patients. The underlying mechanisms of these associations remain to be investigated.
Keywords
Age Factors, Aged, Disease Progression, Female, France, Humans, Male, Middle Aged, Multivariate Analysis, Predictive Value of Tests, Severity of Illness Index, Statistics, Nonparametric, Stroke/blood, Stroke/diagnosis, Vitamin D/analogs & derivatives, Vitamin D/blood
Pubmed
Web of science
Create date
23/08/2024 8:26
Last modification date
11/09/2024 8:37
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