Normalisation de la sécrétion de rénine par le neuropeptide Y chez les rats surrénalectomisés avec hypertension induite par les glucocorticoïdes [Normalization of renin secretion by neuropeptide Y in adrenalectomized rats with glucocorticoid-induced hypertension]
Details
Serval ID
serval:BIB_6BB874EAC270
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Normalisation de la sécrétion de rénine par le neuropeptide Y chez les rats surrénalectomisés avec hypertension induite par les glucocorticoïdes [Normalization of renin secretion by neuropeptide Y in adrenalectomized rats with glucocorticoid-induced hypertension]
Journal
Archives des Maladies du Coeur et des Vaisseaux
ISSN
0003-9683
Publication state
Published
Issued date
06/1986
Peer-reviewed
Oui
Volume
79
Number
6
Pages
879-881
Language
french
Abstract
In the periphery, neuropeptide Y is present in the circulation, in the adrenal medulla as well as at the level of nerve endings and of the juxtaglomerular apparatus. The aim of the present study was to assess the effect of this neuropeptide on renin secretion. Normotensive rats were biadrenalectomized or sham-operated and made hypertensive with methylprednisolone acetate (20 mg/kg s.c. once weekly). Deoxycorticosterone pivalate (10 mg/kg s.c. once weekly) was also given to prevent mineralocorticoid deficiency. Two weeks after that initial surgery 12 adrenalectomized rats and 8 sham-operated rats were infused for 30 min with neuropeptide Y (0.1 microgram/min) whereas 8 adrenalectomized rats and 9 sham-operated rats received in similar conditions the vehicle of neuropeptide Y (10 microliters/min). At that time, the rats were conscious and there was no significant difference in blood pressure and heart rate between the 4 groups of rats. At the end of the experiment, adrenalectomized rats exhibited a markedly stimulated renin-angiotensin system. Neuropeptide Y made it possible to normalize plasma renin activity in these rats, thus suggesting that neuropeptide Y plays an important role in regulating renin secretion.
Keywords
Adrenalectomy, Animals, Desoxycorticosterone, Hypertension/blood, Hypertension/chemically induced, Male, Methylprednisolone, Neuropeptide Y/therapeutic use, Rats, Rats, Inbred Strains, Renin/blood
Pubmed
Web of science
Create date
05/03/2008 17:39
Last modification date
20/08/2019 15:25