Genetic control of lung development

Details

Serval ID
serval:BIB_6BAB51835D91
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Genetic control of lung development
Journal
Biology of the Neonate
Author(s)
Roth-Kleiner  M., Post  M.
ISSN
0006-3126
Publication state
Published
Issued date
2003
Peer-reviewed
Oui
Volume
84
Number
1
Pages
83-8
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review
Abstract
Lung organogenesis is a developmental process that starts in human 4-5 weeks after conception and continues during the first years of life. It can be subdivided in six different stages: embryonic, pseudoglandular, canalicular, saccular and alveolar stage and stage of vascular maturation. In each of these periods, multiple molecules like transcription factors, growth factors and other signaling molecules and their respective receptors control and coordinate the course of events by a distinct expression and activity over space and time. Epithelial-mesenchymal interactions, physiological mechanical forces as well as humoral factors modulate some of these expression patterns. Although numerous key players and their mode of action have been discovered, many wait to be unveiled. Herein, we will summarize the current concepts of lung development with special consideration of the genetic control of lung genesis, growth and maturation.
Keywords
Cell Differentiation Child, Preschool Epithelium/embryology Fetal Organ Maturity/*genetics Gestational Age Humans Infant Infant, Newborn Lung/blood supply/*embryology/*growth & development Mesoderm Microcirculation/growth & development Pulmonary Alveoli/embryology Trachea/embryology
Pubmed
Web of science
Create date
24/01/2008 21:41
Last modification date
20/08/2019 15:25
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