Short-term and long-term effects of major depressive disorder subtypes on obesity markers and impact of sex on these associations.

Details

Serval ID
serval:BIB_6B9BD5C7517D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Short-term and long-term effects of major depressive disorder subtypes on obesity markers and impact of sex on these associations.
Journal
Journal of affective disorders
Author(s)
Ottino C., Strippoli M.F., Gholam M., Lasserre A.M., Vandeleur C.L., Vollenweider P., Marques-Vidal P., Clair C., Preisig M.
ISSN
1573-2517 (Electronic)
ISSN-L
0165-0327
Publication state
Published
Issued date
27/10/2021
Peer-reviewed
Oui
Volume
297
Pages
570-578
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
Only a few studies with conflicting results have examined the effects of sex on the prospective association between depression and subsequent obesity.
(1) To simultaneously assess the associations of the subtypes (atypical, melancholic, unspecified) of major depressive disorder (MDD) measured at baseline and subtypes of major depressive episodes (MDE) that emerged during a 5.5-year follow-up with changes in obesity markers (body mass index, waist circumference, fat mass) during this follow-up, and (2) to test the effect of sex on these associations.
Data from CoLaus|PsyCoLaus, a population-based cohort study including 2702 participants (50.1% women, mean age 49.6 years). Criteria for mental disorders were elicited using semi-structured interviews.
History of atypical MDD at baseline was associated with a steeper increase in BMI and waist circumference, whereas atypical MDE during follow-up was associated with a steeper increase in the three studied obesity markers. Melancholic MDD at baseline was associated with a steeper increase in BMI. Several significant interactions with sex were found indicating higher increase in fat mass in men than in women following melancholic MDD reported at baseline, higher decrease in BMI and fat mass in women than in men related to melancholic MDE emerging during follow-up and higher increase in waist circumference in men than in women following unspecified MDD reported at baseline.
Urban sample which may not be representative for the whole population.
Our results further advocate for the specific need of a thorough monitoring of obesity markers in patients with atypical MDD and suggest less favorable obesity marker changes mainly related to melancholic MDE in men.
Keywords
longitudinal study, major depressive disorder, metabolic factors, obesity, sex differences, subtypes, Longitudinal study, Major depressive disorder, Metabolic factors, Obesity, Sex differences, Subtypes
Pubmed
Create date
08/11/2021 9:59
Last modification date
12/11/2021 7:40
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