The Rational Use of Complement Inhibitors in Kidney Diseases.

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Version: Final published version
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_6B98D384D8F5
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
The Rational Use of Complement Inhibitors in Kidney Diseases.
Journal
Kidney international reports
Author(s)
Fakhouri F., Schwotzer N., Golshayan D., Frémeaux-Bacchi V.
ISSN
2468-0249 (Electronic)
ISSN-L
2468-0249
Publication state
Published
Issued date
06/2022
Peer-reviewed
Oui
Volume
7
Number
6
Pages
1165-1178
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
The development of complement inhibitors represented one of the major breakthroughs in clinical nephrology in the last decade. Complement inhibition has dramatically transformed the outcome of one of the most severe kidney diseases, the atypical hemolytic uremic syndrome (aHUS), a prototypic complement-mediated disorder. The availability of complement inhibitors has also opened new promising perspectives for the management of several other kidney diseases in which complement activation is involved to a variable extent. With the rapidly growing number of complement inhibitors tested in a rapidly increasing number of indications, a rational use of this innovative and expensive new therapeutic class has become crucial. The present review aims to summarize what we know, and what we still ignore, regarding complement activation and therapeutic inhibition in kidney diseases. It also provides some clues and elements of thoughts for a rational approach of complement modulation in kidney diseases.
Keywords
complement, complement inhibitors, glomerular diseases
Pubmed
Open Access
Yes
Create date
21/06/2022 12:57
Last modification date
23/11/2022 7:11
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