Survival after lung metastasectomy in colorectal cancer patients with previously resected liver metastases.

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Serval ID
serval:BIB_6B9328A6FB42
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Survival after lung metastasectomy in colorectal cancer patients with previously resected liver metastases.
Journal
World Journal of Surgery
Author(s)
Gonzalez M., Robert J.H., Halkic N., Mentha G., Roth A., Perneger T., Ris H.B., Gervaz P.
ISSN
1432-2323 (Electronic)
ISSN-L
0364-2313
Publication state
Published
Issued date
2012
Volume
36
Number
2
Pages
386-391
Language
english
Notes
Publication types: Evaluation Studies ; Journal ArticlePublication Status: ppublish
Abstract
BACKGROUND: Resection of hepatic metastases is indicated in selected stage IV colorectal cancer (CRC) patients. A minority will eventually develop pulmonary metastases and may undergo lung surgery with curative intent. The aims of the present study were to assess clinical outcome and identify parameters predicting survival after pulmonary metastasectomy in patients who underwent prior resection of hepatic CRC metastases.¦METHODS: We performed a retrospective analysis of 27 consecutive patients (median age 62 years; range: 33-75 years) who underwent resection of pulmonary metastases after previous hepatic metastasectomy from CRC in two institutions from 1996 to 2009. All patients underwent complete resection (R0) for both colorectal and hepatic metastases.¦RESULTS: Median follow-up was 32 months (range: 3-69 months) after resection of lung metastases and 65 months (range: 19-146 months) after resection of primary CRC. Three- and 5-year overall survival rates after lung surgery were 56 and 39%, respectively, and median survival was 46 months (95% CI 35-57). Median disease-free survival after pulmonary metastasectomy was 13 months (95% CI 5-21). At the time of last follow-up, seven patients (26%) had no evidence of recurrent disease and 6 of these 7 patients presented initially with a single lung metastasis.¦CONCLUSIONS: Resection of lung metastases from CRC patients may result in prolonged survival, even after previous hepatic metastasectomy. Yet, prolonged disease-free survival remains the exception, and seems to occur only in patients with a single lung lesion.
Keywords
Adult, Aged, Antineoplastic Agents/therapeutic use, Antineoplastic Combined Chemotherapy Protocols/therapeutic use, Chemotherapy, Adjuvant, Colectomy, Colorectal Neoplasms/drug therapy, Colorectal Neoplasms/mortality, Female, Follow-Up Studies, Hepatectomy, Humans, Liver Neoplasms/drug therapy, Liver Neoplasms/mortality, Lung Neoplasms/drug therapy, Lung Neoplasms/mortality, Male, Middle Aged, Pneumonectomy, Retrospective Studies, Survival Analysis, Survival Rate, Treatment Outcome
Pubmed
Web of science
Open Access
Yes
Create date
31/05/2012 18:21
Last modification date
01/10/2019 6:18
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